- NOVEL COMPOUNDS
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The present invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof, wherein n, X1, X2, R1, R2, R3, R4, R5, R6, R7, R8, R9, R10, R11, R12and R13 are as defined in the specification, processes for their preparation, pharmaceutical compositions containing them and their use in therapy.
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- Synthesis and structure-activity relationships of novel 2',2'-difluoro analogues of docetaxel
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To investigate the role of the 2'-hydroxy group at the C-13 side chain of docetaxel in the antitumor activity, we prepared several 2',2'-difluoro derivatives of docetaxel and evaluated their cytotoxicity against mouse leukemia and human tumor cell lines a
- Uoto, Kouichi,Ohsuki, Satoru,Takenoshita, Haruhiro,Ishiyama, Takashi,Iimura, Shin,Hirota, Yasuhide,Mitsui, Ikuo,Terasawa, Hirofumi,Soga, Tsunehiko
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p. 1793 - 1804
(2007/10/03)
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