cas 38186-84-4, 2-Chloro-5-fluoro-3-methylpyridine | Articles data ｜lookchem

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38186-84-4

Articles about 38186-84-4Total 6 be found

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PIPERIDINE DERIVATIVES USEFUL AS OREXIN ANTAGONISTS
This invention relates to imidazopyridylmethylene substituted piperidine derivatives orexin antagonists and their use as pharmaceuticals.
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Page/Page column 26

(2010/07/09)

NOVEL COMPOUNDS
Disclosed are imidazo[1,2-a]pyridin-2-ylmethyl substituted piperidine derivatives of formula (I) and their use as pharmaceuticals.
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Page/Page column 20

(2009/02/11)

Non-basic histamine H1-antagonists. I. Synthesis and biological evaluation of some substituted 2-(2-pyridylaminoalkylamino) pyrimidones and related compounds
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Ife,Catchpole,Durant,Ganellin,Harvey,Meeson,Owen,Parsons,Slingsby,Theobald
p. 249 - 258
(2007/10/02)

2-SUBSTITUTED PROPOXY-3-CYANO-5-HYDROXYPYRIDINES AND USE AS ANTIHYPERTENSIVES
The present application discloses certain 2-substituted propoxy-3-cyano-5-hydroxypyridines. The compounds have pharmaceutical activity e.g. as antihypertensives.
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(2008/06/13)

2-Substituted propoxy-3-cyano-5-RO-pyridines and intermediates
The present application discloses 2-substituted propoxy-3-cyano-5-RO-pyridines and intermediates therefor. The former compounds have pharmaceutical activity.
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(2008/06/13)

Synthesis of 2-Chloro-5-hydroxynicotinonitrile: The Required Intermediate in the Total Synthesis of a Hydroxylated Metabolite of (S)-2-(3-t-Butylamino-2-hydroxypropoxy)-3-cyanopyridine
A convenient method for the synthesis of 2-chloro-5-hydroxynicotinonitrile (10) via 5-amino-2-chloro-3-methylpyridine (3) is described.Subsequent conversions provided the basic metabolite 2 of (S)-2-(3-t-butylamino-2-hydroxypropoxy)-3-cyanopyridine (1). 1
Ponticello, Gerald S.,Engelhardt, Edward L.,Freedman, Mark B.,Baldwin, John J.
p. 445 - 448
(2007/10/02)

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Chemical Properties

Melting Point: 41.0 to 45.0 °C
Boiling Point: 177.928 °C at 760 mmHg
Flash Point:61.409 °C
Density: 1.265 g/cm³
Solubility:soluble in Methanol
Storage Temp.:Inert atmosphere,Room Temperature
Vapor Pressure: 1.369mmHg at 25°C
Refractive Index: 1.504
PKA: -1.59±0.10(Predicted)
PSA: 12.89000
LogP: 2.18250

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