38221-19-1

Basic information

• Product Name: 1-benzofuran-2-ol
• Synonyms: 1-Benzofuran-2-ol; 2-Benzofuranol
• CAS NO: 38221-19-1
• Molecular Formula: C₈H₆O₂
• Molecular Weight: 134.132
• Mol File: 38221-19-1.mol

Chemical Properties

• Boiling Point: 247.139°C at 760 mmHg
• Flash Point: 103.267°C
• Density: 1.28g/cm³
• Vapor Pressure: 0.017mmHg at 25°C
• Refractive Index: 1.651
• CAS DataBase Reference: 1-benzofuran-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: 1-benzofuran-2-ol(38221-19-1)
• EPA Substance Registry System: 1-benzofuran-2-ol(38221-19-1)

Safety Data

• Hazardous Substances Data: 38221-19-1(Hazardous Substances Data)

Upstream product

• 402503-13-3 2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzo[b]furan 
• 98437-24-2 benzofuran-2-boronic acid 

Downstream Products

• 770745-88-5 4-(2,3,4,6-O-acetyl-β-D-glucopyranosyloxy)-3-[2-(4-carbamoyl)ethyl]benzofuran 

Relevant articles and documents

Versatile catalysis of “natural extract”: oxidation of sulfides and alcohols and ipso-hydroxylation of arylboronic acids

Abstract: In the present work, we have described the versatile applications of naturally available inexpensive citrous lemon juice as biocatalyst for controlled oxidation of sulfides and alcohols and ipso-hydroxylation of arylboronic acids using 30% H2O2 as a green oxidant. A series of structurally divergent sulfides and benzyl alcohols were oxidized to their corresponding sulfoxides and aldehydes, respectively, with good-to-excellent yields. Similarly, aryl and heteroaryl boronic acids were rapidly, often within minutes, transformed to their corresponding phenols at room temperature. Graphic abstract: [Figure not available: see fulltext.]

Chemoselective oxidation of aryl organoboron systems enabled by boronic acid-selective phase transfer

We report the direct chemoselective Brown-type oxidation of aryl organoboron systems containing two oxidizable boron groups. Basic biphasic reaction conditions enable selective formation and phase transfer of a boronic acid trihydroxyboronate in the presence of boronic acid pinacol (BPin) esters, while avoiding speciation equilibria. Spectroscopic investigations validate a base-promoted phase-selective discrimination of organoboron species. This phenomenon is general across a broad range of organoboron compounds and can also be used to invert conventional protecting group strategies, enabling chemoselective oxidation of BMIDA species over normally more reactive BPin substrates. We also demonstrate the selective oxidation of diboronic acid systems with chemoselectivity predictable a priori. The utility of this method is exemplified through the development of a chemoselective oxidative nucleophile coupling.

Pharmaceutical compounds and methods of use thereof

The present invention provides substituted benzofuran, indene, thianaphthene and oxidized thianaphthene compounds and methods of treatment and pharmaceutical compositions that comprise such compounds. Preferred compounds of the invention contain benzofuran, indene or thianaphthene group substituted with a tetrahydrofuran or other alicyclic group.

Dibenzonaphthyrones

Dibenzonaphthyrone of formula (I) wherein A1and A2independently of each other are unsubstituted or mono- to tetra-substituted o-C6-C18arylene, with the proviso that formula (I) does not represent a dibenzonaphthyrone of the formula The invention further relates to processes for the preparation thereof, to the use thereof for colouring/pigmenting high-molecular-weight organic material and to substance compositions comprising dibenzonaphthyrones.

Process for preparing 2,3-dihydro-2,2-dimethyl-7-hydroxybenzofuran

A process for preparing 2,3-dihydro-2,2-dimethyl-7-hydroxybenzofuran which comprises subjecting o-methallyloxyphenol to a rearrangement and cyclization reactions in the presence of, as a catalyst, aluminum halide and N-substituted aniline derivative, or a complex of both these compounds.