- Synthetic Modifications of Withanolides with an α-Orientated Side-Chain
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In view of the antitumour activity of withanolide E and 4β-hydroxywithanolide E, synthetically modified analogues were prepared.In these compounds, the α-orientation of the side-chain was retained.Its degree of bending with respect to the carbocyclic skeleton depends on the presence or absence of the 14α-OH group.Elimination of this group leads to the formation of the 14,20-oxido-bridged and Δ14-compounds.Epoxidation of the latter afforded 14α,15α-epoxides.With the exception of several 5,6-chlorohydrins, most compounds possess an epoxide ring, allylic or homoallylic with respect to the ring A enone.
- Glotter, Erwin,Kumar, Sandeep,Sahai, Mahendra,Goldman, Alex,Kirson, Isaac,Mendelovici, Marioara
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p. 739 - 745
(2007/10/02)
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