383401-03-4Relevant articles and documents
S-4-Methoxytrityl mercapto acids: Synthesis and application
Mourtas, Spyros,Gatos, Dimitrios,Kalaitzi, Vagiani,Katakalou, Christina,Barlos, Kleomenis
, p. 6965 - 6967 (2007/10/03)
4-Methoxytrityl (Mmt)-mercapto acids were obtained either by the reaction of mercapto acids with Mmt-chloride or by the reaction of halo acids with Mmt-thiol. The derivatives obtained were used in the solid-phase synthesis of small libraries of mercaptoacylamino acids and mercaptoacyl peptides. The removal of the Mmt-group was performed by treatment with trifluoroacetic acid (TFA) in dichloromethane (DCM) using triethylsilane (TES) as scavenger.
Synthesis of pentathymidylate using a 4-monomethoxytritylthio (MMTrS) group as a 5′-hydroxyl protecting group: Toward oligonucleotide synthesis without acid treatment
Seio, Kohji,Sekine, Mitsuo
, p. 8657 - 8660 (2007/10/03)
A phosphoramidite unit having 4-monomethoxytritylthio as a new 5′-hydroxyl protecting group was prepared and employed in oligonucleotide synthesis. The new phosphoramidite enabled the synthesis of oligonucleotides without the use of acids such as TFA or DCA.