- Three-step regioselective synthesis of 2,3-difluorohalobenzenes using tetrafluoroethylene and buta-1,3-diene as starting building blocks
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The gas-phase copyrolysis of tetrafluoroethylene and buta-1,3-diene in a flow tube reactor at 490–510 °C gives 3,3,4,4-tetrafluorocyclohex-1-ene, which is selectively converted to 1-bromo- or 1-chloro-2,3-difluorobenzene via intermediate steps of halogenation and dehydrohalogenation.
- Egorov, M. P.,Lipkind, M. B.,Nefedov, O. M.,Volchkov, N. V.
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p. 925 - 932
(2021/06/07)
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- Preparation method of balosavir intermediate
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The invention discloses a preparation method of a balosavir intermediate, and particularly relates to a method for efficiently synthesizing 7, 8-difluorodibenzo[B, E]thieno-11(6H)one by taking 2, 3-difluorotoluene as a raw material through three steps of
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Paragraph 0019
(2021/02/13)
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- Method for producing tetrakis ( fluoroaryl) borate-magnesium compound
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Fluoroaryl magnesium halide is reacted with a boron compound so that a molar ratio of the fluoroaryl magnesium halide to the boron compound is not less than 3.0 and not more than 3.7, so as to produce a tetrakis (fluoroaryl) borate·magnesium compound. With this method, there occurs no hydrogen fluoride which corrodes a producing apparatus and requires troublesome waste water treatment.
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