- Synthesis method of triamcinolone acetonide
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The invention provides a synthesis method of triamcinolone acetonide, and relates to the technical field of chemical synthesis. The synthesis method of triamcinolone acetonide comprises the followingsteps: (a) carrying out dehydration reaction on a compound shown as a formula I under the action of an alkali reagent to obtain a compound shown as a formula II; (b) carrying out oxidation reaction onthe compound shown in the formula II to obtain a compound shown in a formula III; (c) carrying out epoxy reaction on the compound shown in the formula III and acetone under the action of an acid reagent to obtain a compound shown in a formula IV; and (d) carrying out hydrolysis reaction on the compound shown in the formula IV under the action of an alkali reagent to obtain a compound shown in theformula V. According to the synthesis method of triamcinolone acetonide provided by the invention, the triamcinolone acetonide is obtained through dehydration reaction, oxidation reaction, epoxy reaction and hydrolysis reaction by taking the compound shown as the formula I as an initial raw material, the reaction raw materials are cheap and easy to obtain, the reaction conditions are mild, the synthesis route is greatly shortened, and the yield of the product is increased.
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Paragraph 0113-0120
(2021/01/15)
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- NOVEL PROCESS FOR PREPARATION OF GLUCOCORTICOID STEROIDS
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The present invention discloses a process for the preparation of 16, 17-acetals of pregnane derivatives having formula (I) wherein each substituent is independently selected from; R1 is H or CH3; R2 is C1-C6 linear or branched alkyl, alkynyl group or cycloalkyl group; aryl or heteroaryl group; or R1 and R2 combine to form saturated, unsaturated C3-C6 cyclic or heterocyclic ring; R3 and R4 are same or different and each independently represents H or halogen; R5 is -OH or –OCOR wherein R represents H or C1-C6 linear, branched or cyclic alkyl group that may be substituted.
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