The present invention relates to heterocyclic compounds (e.g., compounds described by Formula (I)) and pharmaceutically acceptable salts thereof. The invention also features pharmaceutical compositions that include these compounds and their use in therapy for treating conditions in which necroptosis is likely to play a substantial role. The heterocyclic compounds described herein can also achieve improved activity and selectivity towards RIP1 and/or RIP3.
-
Page/Page column 57
(2014/09/29)
Synthesis of aplyolide A, ichthyotoxic macrolide isolated from the skin of the marine mollusk Aplysia depilans
A convergent pathway is described for the synthesis of (S)-aplyolide A (1) using ethyl (S)-lactate as chiral source. Key steps of the synthesis are two couplings between copper(I) alkynides and propargylic halides for the formation of skipped diyne systems and were performed with an improved procedure based on the use of cesium carbonate as base for alkynide preparation.
Spinella,Caruso,Martino,Sessa
p. 1971 - 1973
(2007/10/03)
Convenient and general synthesis of 1-monoorganyl- And 1,2-diorganylcyclobutenes via cyclialkylation
-
Negishi, Ei-Ichi,Liu, Fang,Choueiry, Daniele,Mohamud, Mohamud M.,Silveira Jr., Augustine,Reeves, Mark
p. 8325 - 8328
(2007/10/03)
METHOD OF SELECTIVELY INHIBITING CALCIUM-INDEPENDENT MYOCARDIAL PHOSPHOLIPASE A2
Inhibition of calcium-independent myocardial phospholipase A2 is shown for compounds of the formula: wherein R and R1 independently represent hydrogen and halogen, alkyl, alkenyl and alkynyl radicals; R2 represents aryl, aryloxy, and heteroaryl radicals; and X is 1 or 2