387827-69-2

Basic information

• Product Name: 2-(4-FLUOROPHENYL)-6-METHYLPYRIDINE
• Synonyms: 2-(4-FLUOROPHENYL)-6-METHYLPYRIDINE
• CAS NO: 387827-69-2
• Molecular Formula: C₁₂H₁₀FN
• Molecular Weight: 187.2129032
• Mol File: 387827-69-2.mol

Chemical Properties

• Boiling Point: 266.791 °C at 760 mmHg
• Flash Point: 115.152 °C
• Appearance: /
• Density: 1.112 g/cm³
• Vapor Pressure: 0.014mmHg at 25°C
• Refractive Index: 1.551
• CAS DataBase Reference: 2-(4-FLUOROPHENYL)-6-METHYLPYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-FLUOROPHENYL)-6-METHYLPYRIDINE(387827-69-2)
• EPA Substance Registry System: 2-(4-FLUOROPHENYL)-6-METHYLPYRIDINE(387827-69-2)

Safety Data

• Hazardous Substances Data: 387827-69-2(Hazardous Substances Data)

Usage

Molecular structure

A pyridine derivative with a 4-fluorophenyl group and a methyl group attached to the 2nd and 6th carbon atoms, respectively.

Usage

Commonly used as an intermediate in the synthesis of pharmaceutical compounds and agrochemicals.

Application

Can be used as a building block in organic synthesis for the production of various compounds.

Relevance in organic chemistry

The chemical structure of 2-(4-Fluorophenyl)-6-methylpyridine makes it useful for its specific reactivity and properties, making it a valuable tool in the field of organic chemistry.

InChI:InChI=1/C12H10FN/c1-9-3-2-4-12(14-9)10-5-7-11(13)8-6-10/h2-8H,1H3

Upstream product

• 18368-57-5 2-mercapto-6-methylpyridine 
• 281221-71-4 6-methylpyridine-2-sulfonyl chloride 
• 1765-93-1 4-fluoroboronic acid 
• 5315-25-3 2-bromo-6-methylpyridine 
• 10412-98-3 5-oxohexanenitrile 

Relevant articles and documents

Desulfonative Suzuki–Miyaura Coupling of Sulfonyl Fluorides

Sulfonyl fluorides have emerged as powerful “click” electrophiles to access sulfonylated derivatives. Yet, they are relatively inert towards C?C bond forming transformations, notably under transition-metal catalysis. Here, we describe conditions under which aryl sulfonyl fluorides act as electrophiles for the Pd-catalyzed Suzuki–Miyaura cross-coupling. This desulfonative cross-coupling occurs selectively in the absence of base and, unusually, even in the presence of strong acids. Divergent one-step syntheses of two analogues of bioactive compounds showcase the expanded reactivity of sulfonyl fluorides to encompass both S?Nu and C?C bond formation. Mechanistic experiments and DFT calculations suggest oxidative addition occurs at the C?S bond followed by desulfonation to form a Pd-F intermediate that facilitates transmetalation.

ORGANIC METAL COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE

Organic metal compounds, and organic light-emitting devices employing the same are provided. The organic metal compound has a chemical structure of Formula (I): The definitions of R1-R18 and n are as defined in specification. The org

ORGANIC METAL COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE including same

Organic metal compounds, and organic light-emitting devices including the same are provided. The organic metal compound has a chemical structure of Formula (I):The definitions of R1-R18 and n are as defined in specification.

Palladium-Catalyzed Cascade Reactions of I-Ketonitriles with Arylboronic Acids: Synthesis of Pyridines

This study presents the first example of the Pd-catalyzed cascade reactions of 5-oxohexanenitrile with arylboronic acids, affording important synthon 2-methylpyridines that can be further translated through C(sp3)-H functionalization to construct pyridine derivatives. Furthermore, this chemistry allows 5-oxo-5-Arylpentanenitrile to react with arylboronic acids to provide unsymmetrical 2,6-diarylpyridines. This protocol paves the way for the practical and atom economical syntheses of valuable pyridines with broad functional groups in moderate to excellent yields under mild conditions.

Organometallic COMPOUND AND ORGANIC LIGHT-EMITTING DEVICE

The invention provides an organometallic compound and an organic light-emitting device including the same. The organometallic compound has a structure represented by formula (I), wherein at least oneof R3, R4, R5, R6, R7, R8, R9, R10 and R11 is -Si (R19)

Studies on the amino-heck reactions of unsaturated ketones o-phosphinyloximes for the preparation of substituted pyridines

The amino-Heck cyclization process has been applied into a range of γ,δ-unsaturated ketone O-diethylphosphinyloximes 1 and δ,ε-unsaturated ketone O-diethylphosphinyloximes 7. Under the specific catalytic conditions developed by us, these substrates were found to preferentially undergo the 6-endo cyclization to give the formation of 2-substituted pyridines 3 and substituted methylpyridines 8, respectively, in moderate to good yields. Besides, several interesting aspects on the effects of phosphinyl groups, solvents, bases and molecular sieves on the regioselectivity of the cyclization of 1 have also been realized.