- Cobalt-Catalyzed (E)-β-Selective Hydrogermylation of Terminal Alkynes
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A cobalt-catalyzed method for the hydrogermylation of alkynes is reported, providing a selective and accessible route to (E)-β-vinyl(trialkyl)germanes from terminal alkynes and HGeBu3. As shown in multiple examples, the developed method demonstrates a broad functional group tolerance an practical utility for late-stage hydrogermylation of natural products. The method is compatible with alkynes bearing both aryl and alkyl substituents, providing unrivaled selectivity for previously challenging 1° alkyl-substituted alkynes. Moreover, the catalyst used in this method, Co2(CO)8, is a cheap and commercially available reagent. Conducted mechanistic studies supported the syn-addition of Bu3GeH to an alkyne π-complex.
- Radzhabov, Maxim R.,Mankad, Neal P.
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supporting information
p. 3221 - 3226
(2021/05/04)
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- Transition metal-catalyzed dehydrogenative germylation of olefins with tri-n-butylgermane
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The catalyzed reaction of an excess of styrene with n-Bu3GeH using several ruthenium and rhodium complexes gave the corresponding vinylgermanes (α-trin-butylgermylstyrene, (Z)-β-tri-n-butylgermylstyrene, and (E)-β-tri-n-butylgermylstyrene), whi
- Furukawa, Naoyuki,Kourogi, Noriko,Seki, Yoshio,Kakiuchi, Fumitoshi,Murai, Shinji
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p. 3764 - 3767
(2008/10/08)
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