Asymmetric Synthesis of L-carbidopa based on a highly enantioselective α-amination
A stereoselective synthesis of l-carbidopa in seven steps and 50% overall yield from commercial compounds is described. The key step involves a highly enantioselective α-amination reaction of an acyclic β-ketoester with di-tert-butyl azodicarboxylate indu
Pericas, Lex,Shafir, Alexandr,Vallribera, Adelina
supporting information
p. 1448 - 1451
(2013/06/27)
Pharmaceutical compositions containing an effervescent acid-base couple
A pharmaceutical composition in the form of effervescent tablets comprising an active ingredient and an effervescent blend, comprising an acidic component and sodium glycine carbonate as alkaline components. Preferred acid components are fumaric acid, maleic acid, and their salts. Tablets are prepared in normal thermohygrometric conditions and with standard tabletting equipment. A pre-granulation process is also disclosed.
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(2008/06/13)
Dual release formulation comprising levodopa ethyl ester and a decarboxylase inhibitor in immediate release layer with levodopa ethyl ester and a decarboxylase inhibitor in a controlled release core
A tablet which comprises: an inner core formulated for controlled release comprising a mixture of (a) a granulated admixture of a decarboxylase inhibitor and a surfactant, and (b) levodopa ethyl ester or a derivative or a pharmaceutically acceptable salt
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(2008/06/13)
More Articles about upstream products of 38821-49-7
Solubility:Slightly soluble in water, very slightly soluble in ethanol (96 per cent), practically insoluble in methylene chloride. It dissolves in dilute solutions of mineral acids.
Storage Temp.:Keep in dark place,Inert atmosphere,Room temperature