- Synthesis and thermal, fluorescence and structural studies of mixed-ligand lead(II) complexes with 2,2'-diamino-5,5'-dimethyl-4,4'-bithiazole
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The synthesized ligand (DADMBTZ = 2,2'-diamino-5,5'-dimethyl-4,4'- bithiazole) is used for preparing these two new 1: 2 adducts of [Pb(DADMBTZ)2(NO3)X] X = CH3COO (1) and CLO4 (2) complexes. Characterization was done by IR, 1H-and 13C-NMR spectroscopy, elemental analysis, and single crystal X-ray determination. UV-Vis and fluorescence spectra were studied. Thermal stabilities of 1 and 2 were studied by thermal gravimetric (TG) and differential thermal analysis (DTA). The coordination number of Pb in 1 is seven (four by the chelating DADMBTZ, two oxygens of acetate and one oxygen of nitrate), whereas in 2 it is five (four by the chelating DADMBTZ and one oxygen of nitrate). Coordination geometries of 1 and 2 show a possible vacant site around Pb(II), occupied possibly by a stereoactive lone pair of electrons on lead(II); coordination around lead is hemidirected with a significant gap trans to chelating DADMBTZ, nitrate, and acetate. Both 1 and 2 make 3-D networks via N-H O and N-H N hydrogen bonds; O-H O hydrogen bonds are found in the network for 1.
- Hosseinian, Akram,Mahjoub, Ali Reza
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- SYNTHESIS, CRYSTAL STRUCTURE, AND DFT INSIGHT OF A NEW TRIGONAL BIPYRAMIDAL ZINC(II) COMPLEX
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Abstract: Bithiazole is considered as a domain of bleomycin which is countered as a chemotherapeutic drug to treat many types of cancer. Hence, the trend towards the design of model compounds containing the bithiazole moiety is increased recently. In this regard, the 2,2′-diamino-5,5′-dimethyl-4,4′-bithiazole organic ligand (L) is synthesized via a condensation reaction of 3,4-diaminobenzophenone with 2,3-butanedione monoxime. Moreover, its zinc(II) complex [Zn(L)3](NO3)2CH3OH (ZnL3) is synthesized and subsequently characterized by various analytical techniques, including Infrared spectroscopy, proton nuclear magnetic resonance, carbon nuclear magnetic resonance, thermal gravimetric-differential thermal analysis, and single crystal X-ray diffraction. Based on single crystal X-ray data, the ZnL3 complex belongs to the triclinic system with the space group P-1. In ZnL3, one of L ligands acts as a monodentate ligand to form the five-coordinated Zn(II) complex, giving a distorted trigonal bipyramidal geometry around the metal atom. Finally, UV-Vis and fluorescence spectroscopy is used to investigate the photophysical properties of the material explained via density functional theory.
- Chamack, M.,Hosseinian, A.,Khazaee, Z.
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p. 1043 - 1055
(2021/08/17)
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- Method for alpha-position bromination of adjacent diketone
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The invention discloses a method for alpha-position bromination of adjacent diketone and belongs to the technical field of halogenating reaction. The method includes: adding adjacent diketone and bromate in a halogenated solvent, dropwise adding hydrogen bromide under the condition of 10-40DEG C, wherein molar ratio of adjacent diketone, bromate and hydrogen bromide is 1:0.7-1.2:2.0-5.0; after dropwise adding, slowly raising the temperature to be 30-50DEG C for stirring reaction, and 1-10 hours after stirring reaction, performing standing reaction for 2-12 hours at 30-50DEG C; after reaction,adding or not adding an extracting agent and taking a corresponding bromide product obtained from organic-phase separation. The bromate and hydrogen bromide which have oxidizability are taken as bromide reagents for bromination, high electricity and stable and safe reaction are achieved, generation of by-products is obviously reduced, yield is improved to some extent, and material transportation and storage is safe; in aftertreatment of feed liquid, the product can be separated by direct liquid separation, and the high-purity product can be obtained through simple distillation.
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Paragraph 0022; 0023; 0024-0026; 0029; 0030; 0032; 0033
(2018/03/02)
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- Potential use of alginate beads as a chondrocyte delivery vehicle and stepwise dissolving porogen in a hydrogel scaffold for cartilage tissue engineering
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The submicron- or nano-sized pores and uncontrollable degradation of conventional hydrogels have severely constrained cell growth and neo-tissue formation. In this study, alginate beads are explored as both delivery vehicles of chondrocytes and stimuli-responsive porogens within hydrogel scaffolds for cartilage tissue engineering. A typical chondroitin sulfate (CS)-alginate beads composite gel (CS-ABG) is fabricated by photo-encapsulating alginate beads into the CS gel, and subsequently batch-wise dissolution and leaching out of the alginate beads is achieved by twice exposing CS-ABG to chelating agents. The combining and gradual removal of alginate beads effectively modulate the gel's physical properties (e.g. swelling ratio, crosslink density) as well as create macro-scale cavities within CS-ABG. The efficacy of CS-ABG as a scaffold for cartilage tissue engineering is compared with a conventional photocrosslinked CS gel (CS-G). The CS-ABG constructs are developed by co-encapsulating chondrocytes and cell-laden alginate beads within the CS gel body and undergo EDTA treatment on day 7 and 14 of culture, respectively, for stepwise removal of the alginate beads. The chondrocytes cultured in CS-ABG constructs exhibit higher cell viability and proliferation, enhanced cartilage-specific gene expressions as well as ECM production compared with those in CS-G constructs. This study demonstrates the potential of alginate beads as cell delivery vehicles and gradually dissolving porogens within gel scaffolds for cartilage tissue engineering.
- Fan, Changjiang,Wang, Dong-An
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p. 80688 - 80697
(2015/10/05)
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