- Lactonization with concomitant 1,2-aryl migration and alkoxylation mediated by dialkoxyphenyl iodides generatedin situ
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A series of alkoxylated isobenzofuranones were conveniently synthesized from the reaction of 2-(1-arylvinyl)benzoic acids with PhI(OR)2, generatedin situfrom the reaction of iodosobenzene (PhIO) with alkyl alcohols. This hypervalent iodine medi
- Cheng, Yifu,Du, Yunfei,He, Jiaxin,Jalil, Ayesha,Li, Guangchen,Yu, Zhenyang,Zhang, Jingran,Zhao, Kang
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p. 7426 - 7429
(2021/08/03)
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- Synthetic method of isobenzofuran-1(3H)-one compound
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The invention discloses a synthetic method of an isobenzofuran-1 (3H)-one compound. The synthetic method comprises the following steps: dissolving a raw material, namely a 2-(1-phenylethylene)benzoic acid compound II in methanol, adding diacetoxyiodobenzene, and conducting reacting to obtain an isobenzofuran-1 (3H)-one compound I. A reaction equation is as described in the specification. The method has the advantages of simple operation, cheap and easily available raw materials, mild reaction conditions, short reaction time, high yield and the like.
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Paragraph 0027-0031
(2021/07/28)
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- Reactions of Carbonyl Compounds in Basic Solutions. Part 9. Methoxide-catalysed Cyclization of Benzylidenephthalides and Methyl o-Phenylacetylbenzoates
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The detailed mechanism of the methoxide-catalysed rearrangement of substituted benzylidenephthalides and both normal and pseudo methyl o-phenylacetylbenzoates to form 2-phenylindane-1,3-diones has been studied.A rate-acidity function correlation for the reactions in methanolic dimethyl sulphoxide (DMSO) shows a linear increase in rate with increasing H- to reach a maximum in rate before decreasing, except for the p-nitro substrate.This derivative shows a rate decrease throughout the H- range.The ρ values in methanol and in 94 mol percent methanolic DMSO are 1.7 and -1.6, respectively.The kinetic isotope effect has been observed with kH/kD 0.8-1.0.The equilibrium constants for ring-chain tautomerism of the methyl o-phenylacetylbenzoates have been determined and shown to be independent of substituent and solvent composition.The rate-determining step is the intramolecular attack of the anion of the normal ester on the ester carbonyl group.In methanol and methanolic DMSO of high methanol content this is preceded by the ionization equilibrium of the normal ester.In methanolic DMSO of low methanol content and for the p-nitro substrate, the initial state is the anion itself.
- Bowden, Keith,Chehel-Amiran, Mohsen
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p. 2031 - 2034
(2007/10/02)
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- The Synthesis of 2-(5-Phenylthiazol-4-yl)benzoic Acids
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The four-step synthesis of 2-(5-phenylthiazol-4-yl)benzoic acid (2a), and its 2-amino derivatives (2b), required for testing as potential plant growth regulators, is described.The α-bromo ketone (9b) was conveniently prepared from commercially available 3
- Teitei, Tsutomu
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p. 605 - 611
(2007/10/02)
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