39156-67-7

Basic information

• Product Name: DIHYDROCYTOCHALASIN B
• Synonyms: DIHYDROCYTOCHALASIN B;CYTOCHALASIN B, DIHYDRO;7(S),20(R)-dihydroxy-16(R)-methyl-10-phenyl-24-oxa[14]cytochalasa-6(12),13(E)-diene-1,23-dione;(7S,13E,16R,20R)-7,20-Dihydroxy-16-methyl-10-phenyl-24-oxa[14]cytochalasa-6(12),13-diene-1,23-dione;(7S,13E,16R,20R)-7β,20-Dihydroxy-16-methyl-10-phenyl-24-oxa[14]cytochalasa-6(12),13-diene-1,23-dione;21,22-Dihydrocytochalalsin B;DHCB;Dihidrocytochalasin B
• CAS NO: 39156-67-7
• Molecular Formula: C₂₉H₃₉NO₅
• Molecular Weight: 481.62
• EINECS: 254-324-4
• Product Categories: Actin Inhibitors and Probes;Cell Signaling and Neuroscience;Cytoskeleton and Extracellular Matrix;antibiotic
• Mol File: 39156-67-7.mol

Chemical Properties

• Melting Point: 203-205 °C
• Boiling Point: 727.5 °C at 760 mmHg
• Flash Point: 393.8 °C
• Appearance: /
• Density: 1.19 g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.584
• Storage Temp.: −20°C
• PKA: 13.65±0.70(Predicted)
• CAS DataBase Reference: DIHYDROCYTOCHALASIN B(CAS DataBase Reference)
• NIST Chemistry Reference: DIHYDROCYTOCHALASIN B(39156-67-7)
• EPA Substance Registry System: DIHYDROCYTOCHALASIN B(39156-67-7)

Safety Data

• Hazard Codes: T+,T
• Statements: 26/27/28-40
• Safety Statements: 22-36/37/39-45
• RIDADR: UN 2811 6.1/PG 2
• WGK Germany: 3
• RTECS: RO0205000
• HazardClass: 6.1(a)
• PackingGroup: I
• Hazardous Substances Data: 39156-67-7(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
Dihydrocytochalasin B is used as a pharmaceutical agent for its ability to alter cell morphology and motility. It is particularly valuable in research and development for understanding cellular processes and potentially in the treatment of conditions related to cell movement and structure.
Used in Research Applications:
In the field of biological and medical research, Dihydrocytochalasin B is used as a research tool to study the effects of various factors on cell shape, movement, and overall function. Its use in laboratories helps scientists gain insights into cellular mechanisms and develop targeted therapies for various diseases.
Used in Drug Development:
Dihydrocytochalasin B is also utilized in the development of new drugs, particularly those aimed at targeting cell motility and morphology. Its unique properties make it a valuable compound in the creation of novel therapeutics for a range of conditions, including cancer and other diseases characterized by abnormal cell behavior.

InChI:InChI=1/C29H39NO5/c1-18-9-7-13-22(31)15-16-25(32)35-29-23(14-8-10-18)27(33)20(3)19(2)26(29)24(30-28(29)34)17-21-11-5-4-6-12-21/h4-6,8,11-12,14,18-19,22-24,26-27,31,33H,3,7,9-10,13,15-17H2,1-2H3,(H,30,34)/b14-8+/t18-,19-,22+,23-,24-,26+,27+,29-/m0/s1

Upstream product

• 14930-96-2 cytochalasin B 
• 14930-96-2 cytochalasin B 
• 14110-64-6 cytochalasin A 
• 14930-96-2 Phomin 

Downstream Products

• 39156-72-4 7β,20β-dimethoxy-2,16α-dimethyl-10-phenyl-24-oxa-[14]cytochalasa-6(12),13t-diene-1,23-dione 
• 39156-71-3 7β,20β-dimethoxy-16α-methyl-10-phenyl-24-oxa-[14]cytochalasa-6(12),13t-diene-1,23-dione 

Relevant articles and documents

CYTOCHALASINS: STRUCTURE-ACTIVITY RELATIONSHIPS

Seven cytochalasins, 7-O-acetylcytochalasin A and two derivatives of cytochalasin B were assayed for Pseudomonas syringae, Bacillus megaterium, and for Geotrichum candidum.Their ability to inhibit the growth of tomato seedlings and their toxicity to brine shrimp (percent larvae mortality) were also investigated.Among the compounds assayed only cytochalasin A showed antibiotic and fungicidal activity.Toxicity to tomato seedlings was exhibited by both - and -macrocyclic cytochalasins, while the activity decreased in the derivatives acetylated on the 7-hydroxy groupand markedly in cytochalasin E.In the brine shrimp bioassay, cytochalasin E was the most active mycotoxin, but generally, at low concentrations, the cytochalasins with the -macrocyclic ring were more active than those with the -macrocyclic ring; cytochalasin A appeared to be the most toxic.