- Structure-activity relationship study of a novel necroptosis inhibitor, necrostatin-7
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Necroptosis is a regulated caspase-independent cell death mechanism characterized by morphological features resembling non-regulated necrosis. Necrotatin-7 (Nec-7), a novel potent small-molecule inhibitor of necroptosis, is structurally distinct from previously described necrostatins (Nec-1, Nec-3, Nec-4 and Nec-5). Here, we describe a series of structural modifications and the structure-activity relationship (SAR) of the Nec-7 series for inhibiting necroptosis.
- Zheng, Weihong,Degterev, Alexei,Hsu, Emily,Yuan, Junying,Yuan, Chengye
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scheme or table
p. 4932 - 4935
(2009/05/26)
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- Synthesis of 3-substituted arylpyrazole-4-carboxylic acids
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A method was suggested for preparing previously unknown 3-aryl-substituted pyrazole-4-carboxylic acids, involving Vilsmeier formylation of semicarbazones of 26 available mono- and disubstituted acetophenones and 2-acetylthiophene followed by oxidation of
- Lebedev,Lebedeva,Sheludyakov,Kovaleva,Ustinova,Kozhevnikov
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p. 782 - 789
(2007/10/03)
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- DIORGANOSILICON(IV) COMPLEXES OF FLUORO-IMINES: SYNTHETIC, SPECTROSCOPIC AND BIOLOGICAL ASPECTS
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The synthetic, spectroscopic and biological studies of some diorganosilicon(IV) complexes derived from fluoroimines having NS and NO donor systems have been undertaken. The fluoroimines were prepared by the condensation of 2-Fluorobenzaldehyde and 1-(2-Fl
- Saxena, Chitra,Singh, R. V.
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