- Synthesis of α-Aryldiazophosphonates via a Diazo Transfer Reaction
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The simple synthetic procedure for preparation of α-aryl-α-diazophosphonates via a diazo transfer reaction is proposed. Benzylphosphonates reacted with tosyl azide (TsN3) in the presence of potassium tert-butoxide (KOtBu) to afford diazophosphonates in a yield up to 79%. The proposed method is general. The reaction uses easily available starting materials, tolerates various functional groups, and may be applied for multi-gram scale synthesis.
- Beletskaya, Irina P.,Titanyuk, Igor D.
-
p. 2748 - 2757
(2022/03/14)
-
- Selective hydrolysis of phosphorus(v) compounds to form organophosphorus monoacids
-
An azide and transition metal-free method for the synthesis of elusive phosphonic, phosphinic, and phosphoric monoacids has been developed. Inert pentavalent P(v)-compounds (phosphonate, phosphinate, and phosphate) are activated by triflate anhydride (Tf2O)/pyridine system to form a highly reactive phosphoryl pyridinium intermediate that undergoes nucleophilic substitution with H2O to selectively deprotect one alkoxy group and form organophosphorus monoacids.
- Ash, Jeffrey,Cordero, Paula,Huang, Hai,Kang, Jun Yong
-
p. 6007 - 6014
(2021/07/21)
-
- Determination and application of the excited-state substituent constants of pyridyl and substituted phenyl groups
-
Thirty six 1-pyridyl-2-arylethenes XCH=CHArY (abbreviated XAEY) were synthesized, in which, X is 2-pyridyl, 3-pyridyl and 4-pyridyl and Y is OMe, Me, H, Br, Cl, F, CF3, and CN. Their ultraviolet absorption spectra were measured in anhydrous ethanol, and their wavelengths of absorption maximum λmax were recorded. Also, the 234 λmax values of 1-substituted phenyl-2-arylethylene compounds (XAEY, where X is substituted phenyl) were collected. The excited-state substituent constants (Formula presented.) of three pyridyl groups and 23 substituted phenyl groups (total of 26) were obtained by means of curve-fitting method. Taking the λmax values of 358 samples of bi-arylethene derivatives as a data set and 126 samples of bi-aryl Schiff bases (including nine compounds synthesized by this work) as another data set, quantitative correlation analyses were performed by employing the obtained (Formula presented.) as a parameter, and good results were obtained for the two data sets. The reliability of the obtained (Formula presented.) values was verified. The results of this paper can provide excited-state substituent constants for the study and application of optical properties of conjugated organic compounds containing aryl groups.
- Cao, Chao-Tun,Yan, Lu,Cao, Chenzhong
-
-
- Tetrahydroquinolinyl phosphinamidates and phosphonamidates enhancing tolerance towards drought stress in crops via interaction with ABA receptor proteins
-
New phosphorous-containing lead structures against drought stress in crops interacting with RCAR/(PYR/PYL) receptor proteins were identified starting from in-depth SAR studies of related sulfonamide lead structures and protein docking studies. A converging 6-step synthesis via phosphinic chlorides and phosphono chloridates as key intermediates afforded envisaged tetrahydroquinolinyl phosphinamidates and phosphonamidates. Whilst tetrahydroquinolinyl phosphonamidates 13a,b exhibited low to moderate target affinities, the corresponding tetrahydroquinolinyl phosphinamidates 12a,b revealed confirmed strong affinities for RCAR/ (PYR/PYL) receptor proteins in Arabidopsis thaliana on the same level as essential plant hormone abscisic acid (ABA) combined with promising efficacy against drought stress in vivo (broad-acre crops wheat and canola).
- Decker, Luka J. B.,Dittgen, Jan,Frackenpohl, Jens,Freigang, J?rg,Génix, Pierre,Helmke, Hendrik,Lange, Gudrun,Luemmen, Peter,Schmidt, Jana,Schmutzler, Dirk,Vors, Jean-Pierre
-
-
- Direct Aryloxylation/Alkyloxylation of Dialkyl Phosphonates for the Synthesis of Mixed Phosphonates
-
A strategy for the direct functionalization strategy of inertial dialkyl phosphonates with hydroxy compounds to afford diverse mixed phosphonates with good yields and functional-group tolerance has been developed. Mechanistic investigations involving both NMR studies and DFT studies suggest that an unprecedented highly reactive PV species (phosphoryl pyridin-1-ium salt), a key intermediate for this new synthetic transformation, is generated in situ from dialkyl phosphonate in the presence of Tf2O/pyridine.
- Huang, Hai,Denne, Johanna,Yang, Chou-Hsun,Wang, Haobin,Kang, Jun Yong
-
supporting information
p. 6624 - 6628
(2018/05/14)
-
- TRIARYLAMINE HYDRAZONE DERIVATIVE AND ELECTROPHOTOGRAPHIC PHOTORECEPTOR
-
PROBLEM TO BE SOLVED: To provide a compound that improves the electric characteristics of electrophotographic photoreceptors. SOLUTION: A triarylamine hydrazone compound is represented by formula (1) or a specific structure (R1 and R2 are halogen, an alkyl group, an alkoxy group, or an aryl group). SELECTED DRAWING: None COPYRIGHT: (C)2017,JPOandINPIT
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-
Paragraph 0191-0193
(2017/08/02)
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- TRIARYLAMINE DERIVATIVE, ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER, AND METHOD FOR PRODUCING ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER
-
A triarylamine derivative represented by general formula (1) below. In the general formula (1), R1, R2, R4, R5, R6, R7, R8, and R9 each represent, independently from one another, a hydrogen atom, an optionally substitute alkyl group having a carbon number of at least 1 and no greater than 6, an optionally substituted alkoxy group having a carbon number of at least 1 and no greater than 6, or an optionally substituted aryl group having a carbon number of at least 6 and no greater than 14, R3 represents an alkyl group having a carbon number of at least 1 and no greater than 4, X represents an alkylene group having a carbon number of at least 1 and no greater than 6 or an oxygen atom, and n represents an integer of 1 to 3.
- -
-
Paragraph 0045; 0164; 0165
(2017/05/28)
-
- TRIARYLAMINE HYDRAZONE COMPOUND AND ELECTROPHOTOGRAPHIC PHOTORECEPTOR
-
PROBLEM TO BE SOLVED: To provide a compound that improves the electric characteristics of electrophotographic photoreceptors. SOLUTION: A triarylamine hydrazone compound is represented by formula (1) (R1-R6 independently represent halogen, a substituted/unsubstituted C1-6 alkyl group, a C1-6 alkoxy group or a substituted/unsubstituted C6-14 aryl group; a is an integer of 1 to 3 or less; b and c independently represent 0 or 1; d, e, f, g, h and i independently represent an integer of 0-5). SELECTED DRAWING: Figure 1 COPYRIGHT: (C)2017,JPOandINPIT
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-
Paragraph 0165-0167
(2017/07/23)
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- TRIARYLAMINE HYDRAZONE COMPOUND AND ELECTROPHOTOGRAPHIC PHOTORECEPTOR
-
PROBLEM TO BE SOLVED: To provide a compound that improves the electric characteristics of electrophotographic photoreceptors. SOLUTION: A triarylamine hydrazone compound is represented by general formula (1) (R1-R6 independently represent a halogen atom, a substituted/unsubstituted C1-6 alkyl group, a substituted/unsubstituted C1-6 alkoxy group or a substituted/unsubstituted C6-14 aryl group; a is an integer of 1 to 3 or less; b-g independently represent an integer of 0-5). SELECTED DRAWING: Figure 1 COPYRIGHT: (C)2017,JPOandINPIT
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-
Paragraph 0168; 0169
(2017/08/03)
-
- Activation of anti-oxidant Nrf2 signaling by substituted trans stilbenes
-
Nrf2, which is a member of the cap'n’ collar family of transcription factors, is a major regulator of phase II detoxification and anti-oxidant genes as well as anti-inflammatory and neuroprotective genes. The importance of inflammation and oxidative stress in many chronic diseases supports the concept that activation of anti-oxidant Nrf2 signaling may have therapeutic potential. A number of Nrf2 activators have entered into clinical trials. Nrf2 exists in the cytosol in complex with its binding partner Keap1, which is a thiol-rich redox-sensing protein. In response to oxidative and electrophilic stress, select cysteine residues of Keap1 are modified, which locks Keap1 in the Nrf2-Keap1 complex and allows newly synthesized Nrf2 to enter the nucleus. Numerous Nrf2-activating chemicals, including a number of natural products, are electrophiles that modify Keap1, often by Michael addition, leading to activation of Nrf2. One concern with the design of Nrf2 activators that are electrophilic covalent modifiers of Keap1 is the issue of selectivity. In the present study, substituted trans stilbenes were identified as activators of Nrf2. These activators of Nrf2 are not highly electrophilic and therefore are unlikely to activate Nrf2 through covalent modification of Keap1. Dose-response studies demonstrated that a range of substituents on either ring of the trans stilbenes, especially fluorine and methoxy substituents, influenced not only the sensitivity to activation, reflected in EC50values, but also the extent of activation, which suggests that multiple mechanisms are involved in the activation of Nrf2. The stilbene backbone appears to be a privileged scaffold for development of a new class of Nrf2 activators.
- Deck, Lorraine M.,Whalen, Lisa J.,Hunsaker, Lucy A.,Royer, Robert E.,Vander Jagt, David L.
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p. 1423 - 1430
(2017/02/18)
-
- Arylmethyl phosphonate preparation method
-
The invention provides an arylmethyl phosphonate preparation method. The method includes the following steps that arylmethyl ester, triethyl phosphate and a catalyst are sequentially added into a reactor and reacted for 5-8 h at the temperature of 100-200 DEG C after full stirring, and after excessive triethyl phosphate is distilled off through decompression, the mixture continues to be reacted for 3-7 h at the temperature of 100-200 DEG C; then, the mixture is cooled to the room temperature, a product is extracted through a mixed solvent, and arylmethyl phosphonate is obtained after the mixed solvent is removed. The catalyst is one or more of tetramethyl ammonium bromide, tetraethylammonium bromide, tetrabutyl ammonium bromide, benzyltrimethyl ammonium bromide, cetyl trimethyl ammonium bromide, cetyltrimethyl ammonium chloride, ammonium chloride, sodium iodide and potassium iodide. Arylmethyl phosphonate is synthesized through a one-step method, other solvents are not added, operation is easy, and the product yield is high and can be 85.3% at maximum.
- -
-
Paragraph 0038; 0039
(2017/01/02)
-
- Difluorocyclobutylacetylenes as positive allosteric modulators of mGluR5 with reduced bioactivation potential
-
Schizophrenia is a serious illness that affects millions of patients and has been associated with N-methyl-D-aspartate receptor (NMDAR) hypofunction. It has been demonstrated that activation of metabotropic glutamate receptor 5 (mGluR5) enhances NMDA receptor function, suggesting the potential utility of mGluR5 positive allosteric modulators (PAMs) in the treatment of schizophrenia. Herein we describe the optimization of an mGluR5 PAM by replacement of a phenyl with aliphatic heterocycles and carbocycles as a strategy to reduce bioactivation in a biaryl acetylene chemotype. Replacement with a difluorocyclobutane followed by further optimization culminated in the identification of compound 32, a low fold shift PAM with reduced bioactivation potential. Compound 32 demonstrated favorable brain uptake and robust efficacy in mouse novel object recognition (NOR) at low doses.
- Degnan, Andrew P.,Maxwell, Darrell,Balakrishnan, Anand,Brown, Jeffrey M.,Easton, Amy,Gulianello, Michael,Hanumegowda, Umesh,Hill-Drzewi, Melissa,Miller, Regina,Santone, Kenneth S.,Senapati, Arun,Shields, Eric E.,Sivarao, Digavalli V.,Westphal, Ryan,Whiterock, Valerie J.,Zhuo, Xiaoliang,Bronson, Joanne J.,Macor, John E.
-
supporting information
p. 5871 - 5876
(2016/12/06)
-
- Triphenylamine derivative, electrophotographic photosensitive member, and image forming apparatus
-
A triarylamine derivative is represented by general formula (I). In general formula (I), R1 and R2 each represent, independently of one another, a chemical group selected from the group consisting of a halogen atom, an optionally substituted alkyl group having a carbon number of 1-6, an optionally substituted alkoxy group having a carbon number of 1-6, and an optionally substituted aryl group having a carbon number of 6-12. In general formula (I), k and l each represent an integer of at least 0 and no greater than 4. When k and l represent integers greater than 1, chemical groups R1 bonded to the same aromatic ring and chemical groups R2 bonded to the same aromatic ring may be the same or different to one another. In general formula (I), m and n each represent a different integer of at least 1 and no greater than 3.
- -
-
Paragraph 0260; 0263; 0264
(2016/10/08)
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- TRIARYLAMINE DERIVATIVE AND ELECTROPHOTOGRAPHIC PHOTOSENSITIVE MEMBER
-
A triarylamine derivative is represented by general formula (1) shown below. In general formula (1), R1, R2, and R3 each represent, independently of one another, a halogen atom, an optionally substituted alkyl group having a carbon number of at least 1 and no greater than 6, an optionally substituted alkoxy group having a carbon number of at least 1 and no greater than 6, or an optionally substituted aryl group having a carbon number of at least 6 and no greater than 12. In general formula (1), o, p, and q each represent, independently of one another, an integer of at least 0 and no greater than 4, and m and n each represent, independently of one another, an integer of at least 1 and no greater than 2.
- -
-
Paragraph 0082; 0083; 0084
(2016/06/28)
-
- TRIARYLAMINE DERIVATIVE, AND ELECTROPHOTOGRAPHIC PHOTORECEPTOR
-
PROBLEM TO BE SOLVED: To provide a triarylamine derivative which allows an electrophotographic photoreceptor to be produced. SOLUTION: A triarylamine derivative is represented by, for example, formula (1). (R1 and R2 are the same or different and each selected from the group consisting of a halogen atom, an optionally substituted C1-6 alkyl group, an optionally substituted C1-6 alkoxy group and an optionally substituted C6-12 aryl group. k and l are each an integer of 0-4; m and n are each an integer of 1-3.) SELECTED DRAWING: Figure 1 COPYRIGHT: (C)2016,JPOandINPIT
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-
Paragraph 0144; 0147
(2016/11/24)
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- Triphenylamine derivative, electrophotographic photosensitive member, and image forming apparatus
-
A triphenylamine derivative is represented by general formula (1). In general formula (1), R1 to R7 each represent, independently of one another, a chemical group selected from the group consisting of a halogen atom, an optionally substituted alkyl group having a carbon number of at least 1 and no greater than 6, an optionally substituted alkoxy group having a carbon number of at least 1 and no greater than 6, and an optionally substituted aryl group having a carbon number of at least 6 and no greater than 12. Also, k, l, m, n, o, and p each represent, independently of one another, an integer of at least 0 and no greater than 4. When any of k, l, m, n, o, or p represents an integer greater than 1, chemical groups R3, R4, R5, R6, or R7 bonded to the same aromatic ring may be the same or different.
- -
-
Paragraph 0253-0256
(2016/10/07)
-
- TRIARYLAMINE DERIVATIVE AND ELECTROPHOTOGRAPHIC PHOTORECEPTOR
-
PROBLEM TO BE SOLVED: To provide a triarylamine derivative excellent in solubility into a solvent and/or compatibility with a binder resin. SOLUTION: There is provided a triarylamine derivative represented by following formula (I). COPYRIGHT: (C)2016,JPOandINPIT
- -
-
Paragraph 0109-0111
(2016/10/07)
-
- Positively chargeable single-layer electrophotographic photosensitive member, process cartridge, and image forming apparatus
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The invention provides a positively chargeable single-layer electrophotographic photosensitive member, a process cartridge, and an image forming apparatus. The positively chargeable single-layer electrophotographic photosensitive member is used as an image support body in an image forming device with a charged portion, wherein the charged portion is in contact with the supporting body and applies pressure to the supporting body. The positively chargeable single-layer electrophotographic photosensitive member comprises a conductive substrate and a photosensitive layer. The photosensitive layer at least contains a charge generating agent, a hole transporting agent, an electron transporting agent and binding resin. The hole transporting agent includes a triarylamine derivative represented by the following general formula (I). In the following general formula (I), R[1], R[2], m and n have the same meanings as those of R[1], R[2], m and n in the specification, respectively.
- -
-
Paragraph 0236; 0238-0239
(2017/03/21)
-
- Reductive coupling reactions: A new strategy for C(sp3)-P bond formation
-
The C(sp3)-P bond forming reaction utilizing N-tosylhydrazones as readily available alkylating reagents was developed, which provides a new opportunity for preparing phosphine oxide derivatives with moderate to good yields. This reductive coupling reaction is proposed to proceed through an insertion of copper carbene into P-H bond of H-phosphorus oxides. The salient features of the reaction are operational simplicity and functional-group tolerance.
- Chen, Zi-Sheng,Zhou, Zhao-Zhao,Hua, Hui-Liang,Duan, Xin-Hua,Luo, Jian-Yi,Wang, Jia,Zhou, Ping-Xin,Liang, Yong-Min
-
p. 1065 - 1068
(2013/02/25)
-
- Design, synthesis and structure-activity relationships of some novel, highly potent anti-invasive (E)- and (Z)-stilbenes
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In our ongoing exploration of the structure-activity landscape of anti-invasive chalcones, we have prepared and evaluated a number of structurally related (E)- and (Z)-stilbenes. These molecules exhibited an extraordinary high in vitro potency in the chick heart invasion assay, being active up to 10 nmol L-1, a concentration level a 100-fold lower than the lowest effective doses that have been reported for natural analogues. Furthermore, they possess an interesting pharmacological profile in silico.
- Roman, Bart I.,De Coen, Laurens M.,Mortier, Séverine Thérèse F.C.,De Ryck, Tine,Vanhoecke, Barbara W.A.,Katritzky, Alan R.,Bracke, Marc E.,Stevens, Christian V.
-
p. 5054 - 5063
(2013/09/02)
-
- Copper-catalyzed synthesis of alkylphosphonates from H-phosphonates and N-tosylhydrazones
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A new catalytic system for the alkylation of H-phosphonates and diphenylphosphine oxide with N-tosylhydrazones has been developed. In the presence of copper(I) iodide and base, H-phosphonates react with N-tosylhydrazones to afford the corresponding coupled alkylphosphonates in good to excellent yields without any ligands. Alkylphosphonates can also be prepared in a one-pot process directly from carbonyl compounds without the isolation of tosylhydrazone intermediates.
- Miao, Wenjun,Gao, Yuzhen,Li, Xueqin,Gao, Yuxing,Tang, Guo,Zhao, Yufen
-
p. 2659 - 2664
(2013/01/15)
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- ELECTROPHOTOGRAPHIC PHOTORECEPTOR
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An object of the present invention is to provide a charge transport material and an electrophotographic photoreceptor using the charge transport material, the charge transport material sufficiently satisfying characteristics conventionally desired for a charge transport material for an electrophotographic photoreceptor, specifically, the charge transport material having a good solubility in a binder polymer, allowing formation of a stable and high-concentration organic thin film therefrom, and having a high carrier mobility. To achieve the object, the present invention provides a tris(4-styrylphenyl)amine derivative represented by the following general formula (1): wherein R1 represents a methyl group or methoxy group, and R2 represents a hydrogen atom, methyl group, or methoxy group, provided that a case where R1 and R2 are a methyl group and R2 is at the meta-position is excluded; wherein 50% or more of geometrical isomers have three double bonds which are all trans.
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-
Page/Page column 10
(2012/02/03)
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- A [2+2] cross-photodimerisation of photostable olefins via a three-component cocrystal solid solution
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A ditopic hydrogen-bond-donor template in the form of resorcinol facilitates a [2+2] cross-photodimerisation of 4-Cl-stilbazole and 4-Me-stilbazole in a rare cocrystal solid solution. A photoreaction does not proceed with the olefins individually or as a solid solution composed solely of the two olefins.
- Buar, Dejan-Kreimir,Sen, Arundhuti,Mariappan, S. V. Santhana,MacGillivray, Leonard R.
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supporting information; experimental part
p. 1790 - 1792
(2012/03/09)
-
- Synthesis, UV/vis spectra and electrochemical characterisation of arylthio and styryl substituted ferrocenes
-
Two series of substituted ferrocenes were synthesised using either the Horner-Wadswor th-Emmons reaction or monolithiation of ferrocene. The series consist of arylthio- and styryl-ferrocenes with different substituents in the para position of the aryl rings of the systems. The electronic communication was investigated by comparing the substituent effects in absorption spectroscopy and in cyclic voltammetry. A small substituent effect was found in the electronic transitions of the styryl substituted ferrocenes. The oxidation of the ferrocene derivatives showed clear substituent effects as illustrated by the linear Hammett plots. The effect was shown to be an order of magnitude larger in the arylthio-systems than in the styryl systems. It is suggested that the reason behind the large effect is a direct sulfur-iron orbital overlap. Versita Sp. z o.o.
- Sorensen, Thomas J.,Nielsen, Merete F.
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experimental part
p. 610 - 618
(2012/04/10)
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- Preparation of benzylphosphonates via a palladium(0)-catalyzed cross-coupling of H-phosphonate diesters with benzyl halides. Synthetic and mechanistic studies
-
We have developed a new, efficient method for the synthesis of benzylphosphonate and benzylphosphonothioate diesters via a palladium(0)- catalyzed cross-coupling reaction between benzyl halides and H-phosphonate or H-phosphonothioate diesters, using Pd2(dba)3(CHCl 3) as a palladium source and Xantphos as a supporting ligand. Some mechanistic aspects of these reactions were investigated using 31P NMR spectroscopy.
- Laven, Gaston,Kalek, Marcin,Jezowska, Martina,Stawinski, Jacek
-
experimental part
p. 967 - 975
(2010/08/04)
-
- Rh-catalyzed Negishi alkyl-aryl cross-coupling leading to α- or β-phosphoryl-substituted alkylarenes
-
The catalytic cross-coupling between ArZnX and ICH2(CH 2)nP(O)(OEt)2 (n = 0-3) has been investigated to determine the utility of the Rh catalyst during the alkyl-aryl cross-coupling and to develop a new syntheti
- Takahashi, Hideki,Inagaki, Shinya,Yoshii, Naoko,Gao, Fuxing,Nishihara, Yasushi,Takagi, Kentaro
-
supporting information; experimental part
p. 2794 - 2797
(2009/09/08)
-
- Palladium(0)-catalyzed benzylation of H-phosphonate diesters: An efficient entry to benzylphosphonates
-
A new, efficient method for the synthesis of benzylphosphonate diesters via a palladium(0)-catalyzed cross-coupling reaction between benzyl halides and H-phosphonate diesters, using Pd(OAc)2 as a palladium source and Xantphos as a supporting ligand, has been developed. Georg Thieme Verlag Stuttgart.
- Lavén, Gaston,Stawinski, Jacek
-
scheme or table
p. 225 - 228
(2009/05/30)
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- Diphenylamine derivative, production method therefor and electrophotographic photoconductor
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The present invention provides a diphenyl amine derivative having the excellent solubility to a solvent and compatibility to a binding resin, an efficient production method therefor, and an electrophotographic photoconductor having the excellent sensitivity, capable of effectively preventing generation of the black dots. A diphenyl amine derivative represented by the following general formula (1) is used: (In the general formula (1), R1 to R12 each are a hydrogen atom, an alkyl group which may have a substituent, or the like, Z is a ring structure linked with a benzene ring, which is a 4 to 8-membered ring including a hydrogen atom, a nitrogen atom, an oxygen atom, a carbon atom or a sulfur atom, m1, m2, n1, n2 each are 0 or 1, m1 + n1 is 1 or 2, and m2 + n2 is 1 or 2.)
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Page/Page column 22
(2010/11/29)
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- Synthesis of a diverse series of phosphacoumarins with biological activity
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(Chemical Equation Presented) We have developed a general and efficient approach to a diverse series of phosphacoumarins as analogues of coumarins with various biological activities, and the inhibitory activity of the synthesized phosphacoumarins against the enzyme SHP-1, a protein tyrosine phosphatases, was tested. Some of them showed moderate to good efficiency.
- Li, Xueshu,Zhang, Dongwei,Pang, Hai,Shen, Feng,Fu, Hua,Jiang, Yuyang,Zhao, Yufen
-
p. 4919 - 4922
(2007/10/03)
-
- Controlled monohalogenation of phosphonates: A new route to pure α- monohalogenated diethyl benzylphosphonates
-
Starting from diethyl benzylphosphonates, a wide variety of diethyl α- monofluoro, chloro, bromo and iodobenzylphosphonates have been obtained in pure form by a one-pot procedure. This high yielding method implies the intermediate protection of the benzyl anion with TMSCI followed by halogenation with an electrophilic halogenating reagent.
- Iorga, Bogdan,Eymery, Frederic,Savignac, Philippe
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p. 2671 - 2686
(2007/10/03)
-
- Use of benzylphosphonic acid derivatives for the treatment of diseases caused by viruses
-
The use of a compound of the formula I STR1 in which V is an alkyl group, fluorine, chlorine, bromine, or iodine, n is an integer from 1 to 5, W is an alkyl, alkenyl, alkynyl or alkoxy group, cyanide, nitro, carboxyl, hydrogen or a cycloalkyl, aryl, aralkyl or carboalkoxy group, R1 and R2 are an alkyl, alkenyl, alkynyl, cycloalkyl or halogenoalkyl group, sodium, potassium, calcium, magnesium, aluminum, lithium, ammonium, triethylammonium or hydrogen, R1 and R2 together form a cyclic diester, R3 and R4 are an alkyl, alkenyl, alkynyl, carboalkoxy, cycloalkyl or alkoxy group, hydrogen, fluorine, chlorine, bromine or iodine and X, Y and Z are oxygen or sulfur, for the treatment of diseases caused by DNA viruses or RNA viruses is described.
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-
-
- New Liquid Crystalline Compounds Based on 1,4-Diarylbuta-1,3-dienes
-
The first group of fully characterised mesogenic (E,E)-1,4-diarylbuta-1,3-dienes, substituted in the para-position of one aryl ring by an alkoxy-group and in the para-position of the other aryl group by a cyano- or halogeno-group has been prepared by a Wadsworth-Emmons procedure; their physical properties of high birefringence and low viscosity in combination make them particularly suitable for use in liquid crystal display devices when mixed with known liquid crystalline materials.
- Brettle, Roger,Dunmur, David A.,Hindley, Nigel J.,Marson, Charles M.
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p. 410 - 411
(2007/10/02)
-
- α-FUNCTIONAL CYCLOALKYLPHOSPHONATES. I. SYNTHESIS
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Cycloalkylphosphonates 2 of different sizes (from cyclopropyl to cycloheptyl) bearing various functional groups Z in α-position were synthesized by bis-alkylation of α-functional methylphosphonates 1 and ω-dibromoalkanes in presence of base.The choice of the basic system is determined by the nature of Z.With powerful electron-withdrawing groups, NaH-THF/DMSO (Method A, for Z = CN, SO2R) or liquid-solid phase transfer process proved to be the more suitable systems.For Z = aryl or SR, lithium diisopropylamide is required to achieve the deprotonation.A wide range of new phoshonates were obtained in high yields on preparative scale.
- Nasser, Jamal,About-Jaudet, Elie,Collignon, Noel
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p. 171 - 179
(2007/10/02)
-