Stereocontrolled total synthesis of (+)-altohyrtin A/spongistatin 1
As an exceptionally potent antimitotic macrolide, altohyrtin A/spongistatin 1 shows great promise in cancer chemotherapy but its extreme scarcity in the natural sponges has halted its further preclinical development. A highly stereocontrolled total synthe
Paterson, Ian,Chen, David Y.-K.,Coster, Mark J.,Acea, Jose L.,Bach, Jordi,Gibson, Karl R.,Keown, Linda E.,Oballa, Renata M.,Trieselmann, Thomas,Wallace, Debra J.
The stereocontrolled total synthesis of altohyrtin A/spongistatin 1: Fragment couplings, completion of the synthesis, analogue generation and biological evaluation
The antimitotic marine macrolide altohyrtin A/spongistatin 1 (1) has been synthesised in a highly convergent and stereocontrolled manner, thus contributing to the replenishment of the largely exhausted material from the initial isolation work. Coupling of
Paterson, Ian,Chen, David Y.-K.,Coster, Mark J.,Acena, Jose L.,Bach, Jordi,Wallace, Debra J.
p. 2431 - 2440
(2007/10/03)
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