- Trisubstituted acridine derivatives as potent and selective telomerase inhibitors
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The synthesis and evaluation for telomerase-inhibitory and quadruplex DNA binding properties of three related series of rationally designed trisubstituted acridine derivatives are described. These are substituted on the acridine ring at the 2,6,9; 2,7,9;
- Harrison, R. John,Cuesta, Javier,Chessari, Gianni,Read, Martin A.,Basra, Sanji K.,Reszka, Anthony P.,Morrell, James,Gowan, Sharon M.,Incles, Christopher M.,Tanious, Farial A.,Wilson, W. David,Kelland, Lloyd R.,Neidle, Stephen
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p. 4463 - 4476
(2007/10/03)
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- Therapeutic acridone and acridine compounds
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The present invention pertains to acridone and acridine compounds of formula (I), wherein either: (a) K is ═O, L is —H, alpha is a single bond, beta is a double bond, gamma is a single bond (acridones); or, (b) K is a 9-substituent, L is absent, alpha is
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Page/Page column 50
(2008/06/13)
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