- Fast synthesis of substituted N-phenylanthranilic acids using Ullmann condensation under microwave irradiation in dry media
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Substituted N-phenylanthranilic acids using the Ullmann condensation under microwave irradiation in dry media were obtained in good yield and short reaction times. Copyright Taylor & Francis LLC.
- Martin, Ana,Mesa, Miriam,Docampo, Maite L.,Gomez, Victoria,Pellon, Rolando F.
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p. 271 - 277
(2007/10/03)
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- Microwave-assisted synthesis of N-phenylanthranilic acids in water
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N-Phenylanthranilic acid derivatives were synthesised using the Ullmann condensation of 2-chlorobenzoic acid with aniline derivatives under microwave irradiation in aqueous media. The method offers better yields in shorter reaction times compared to classical heating approaches using water as solvent.
- Martin, Ana,Pellon, Rolando F.,Mesa, Miriam,Docampo, Maite L.,Gomez, Victoria
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p. 561 - 563
(2007/10/03)
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- Structure-activity relationships in a series of anti-inflammatory N-arylanthranilic acids
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A large series of N-arylanthranilic acids has been prepared. Many of these compounds show high anti-inflammatory activity as measured by the anti-UV-erythema test. From this series have come the clinically useful nonsteroidal anti-inflammatory agents, flufenamic acid (Arlef), mefenamic acid (Ponstel), and the latest and most potent agent, N-(2,6-dichloro-m-tolyl)anthranilic acid (meclofenamic acid, Meclomen = the sodium salt). The structure-activity relationships of this series is discussed and a graphical representation is presented which allows the prediction of activity of new agents.
- Kaltenbronn,Scherrer,Short,Jones,Beatty,Saka,Winder,Wax,Williamson
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p. 621 - 627
(2007/10/02)
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