Pyrazolo[3,4-d]pyrimidine ribonucleosides related to 2-aminoadenosine and isoguanosine: Synthesis, deamination and tautomerism
The syntheses and properties of 8-aza-7-deazapurine (pyrazolo[3,4-d] pyrimidine) ribonucleosides related to 2-aminoadenosine and isoguanosine are described. Glycosylation of 8-aza-7-deazapurine-2,6-diamine 5 with 1-O-acetyl-2,3,5-tri-O-benzoyl-β-d-ribofur
Seela, Frank,Xu, Kuiying
p. 3034 - 3045
(2008/04/01)
7-Substituted 8-aza-7-deazapurines and 2,8-diaza-7-deaza-purines: Synthesis of nucleosides and oligonucleotides
7-Substituted 8-aza-7-deazaadenosines 1a-e were synthesized by Sonogashira cross coupling from the corresponding 7-iodo nucleoside in 36-79% yields. Starting from 7-bromo (or 7-iodo)-8-aza-7-deazaadenine, 2a,b were obtained by acid-catalyzed glycosylation
Lin, Wenqing,Xu, Kuiying,Seela, Frank
p. 869 - 873
(2007/10/03)
Real-time linear detection probes: sensitive 5'-minor groove binder-containing probes for PCR analysis
Oligonucleotide probes/conjugates are provided along with method for their use in assays to monitor amplification wherein the signal produced does not rely on 5′ nuclease digestion.
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(2008/06/13)
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