- Further studies on the application of vinylogous amides and β-halovinylaldehydes to the regiospecific synthesis of unsymmetrical, polyfunctionalized 2,3,4- and 1,2,3,4- substituted pyrroles
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Highly functionalized pyrroles with appropriate regiochemical functionality represent an important class of marine natural products and potential drug candidates. We describe herein a detailed study of the reaction of α-aminoacid esters with vinylogous amides and also β-halovinylaldehydes for the regiospecific synthesis of 2,3,4-trisubstituted and 1,2,3,4-tetrasubstituted pyrroles. Since the vinylogous amides and β-halovinylaldehydes are readily available precursors, rapid access to a wide variety of unsymmetrically substituted pyrroles is accomplished via this methodology.
- Gupton, John T.,Shimozono, Alex,Crawford, Evan,Ortolani, Joe,Clark, Evan,Mahoney, Matt,Heese, Campbell,Noble, Jeffrey,Mandry, Carlos Perez,Kanters, Rene,Dominey, Raymond N.,Goldman, Emma W.,Sikorski, James A.,Fisher, Daniel C.
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p. 2650 - 2663
(2018/04/23)
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- Synthesis, in vitro anti-inflammatory activity and molecular docking studies of novel 4,5-diarylthiophene-2-carboxamide derivatives
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A series of novel 4,5-diarylthiophene-2-carboxamide containing alkyl, cycloalkyl, aryl, aryl alkyl and heterocyclic alkyl moieties were synthesized, characterized and subsequently evaluated for anti-inflammatory property. Among the novel compounds, the inhibition of bovine serum albumin denaturation assay revealed that the aryl and aryl alkyl derivatives of 4,5-diarylthiophene-2-carboxamide showed anti-inflammatory activity comparable to the standard drug diclofenac sodium whereas alkyl and cycloalkyl amide derivatives showed less activity. Docking studies with these compounds against cyclooxygenase-2 receptor (PDB 1D: 1PXX) indicated that they exhibit specific interactions with key residues located in the site of the COX2 structure, which corroborates the hypothesis that these molecules are potential ligands of COX2. The analysis of the docking results, which takes into account the hydrophilic and hydrophobic interactions between the ligands and the target, identified N-(4-bromophenyl)-4,5-bis(4-hydroxyphenyl)thiophene-2-carboxamide (6k) having high binding free energy of ?11.67 kcal /mole (comparable with standard diclofenac sodium) and the best docking score, indicating effective binding of the compound 6k at the active site. [Figure not available: see fulltext.]
- Shanmuganathan,Parthasarathy,Venugopal,Arun,Dhatchanamoorthy,Prince
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p. 117 - 130
(2017/01/24)
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- Synthesis of the Butanamide Derivative S 19812, a New Dual Inhibitor of Cyclooxygenase and Lipoxygenase Pathways
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The general synthetic pathway and the interactions with arachidonic acid metabolism of the new compound S 19812 (N-hydroxy-N-methyl 4-(2,3-bis-(4- methoxyphenyl)-thiophen-5-yl)butanamide, CAS 181308-68-9) were investigated. S 19812 was selected for its we
- Tordjman, Charles,Sauveur, Frederic,Droual, Monique,Briss, Sylvie,Andre, Nathalie,Bellot, Isabelle,Deschamps, Christine,Wierzbicki, Michel
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p. 774 - 779
(2007/10/03)
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