39943-56-1

Basic information

• Product Name: 3,5-DICHLOROPHENYLHYDRAZINE
• Synonyms: 3,5-DICHLOROPHENYLHYDRAZINE;3,5-Dichlorophenylhydrazine,98%
• CAS NO: 39943-56-1
• Molecular Formula: C₆H₆Cl₂N₂
• Molecular Weight: 177.03
• EINECS: -0
• Mol File: 39943-56-1.mol

Chemical Properties

• Melting Point: 111-114°C
• Boiling Point: 286℃
• Flash Point: 127℃
• Appearance: /
• Density: 1.475
• Vapor Pressure: 0.0027mmHg at 25°C
• Refractive Index: 1.665
• PKA: 4?+-.0.10(Predicted)
• BRN: 3126965
• CAS DataBase Reference: 3,5-DICHLOROPHENYLHYDRAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-DICHLOROPHENYLHYDRAZINE(39943-56-1)
• EPA Substance Registry System: 3,5-DICHLOROPHENYLHYDRAZINE(39943-56-1)

Safety Data

• Hazard Codes: Xi
• Statements: 20/21/22-36/37/38
• Safety Statements: 26-36/37/39
• RIDADR: 2811
• HazardClass: IRRITANT-HARMFUL
• Hazardous Substances Data: 39943-56-1(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
3,5-Dichlorophenylhydrazine is used as a reagent in the synthesis of various drugs, contributing to the development of new pharmaceuticals for treating a range of health conditions.
Used in Agrochemical Industry:
3,5-DICHLOROPHENYLHYDRAZINE is utilized as a reagent in the production of agrochemicals, aiding in the creation of substances that protect crops and enhance agricultural productivity.
Used in Dye Manufacturing:
3,5-Dichlorophenylhydrazine is used as a key intermediate in the manufacture of dyes, playing a role in the coloration processes for textiles and other materials.
Used in Pesticide Production:
It serves as a reagent in the synthesis of pesticides, which are crucial for controlling pests and diseases in agriculture and other settings.
Used in Organic Chemistry Research:
3,5-Dichlorophenylhydrazine is used as a reagent for the determination of ketones and aldehydes, facilitating important analytical processes in organic chemistry.
Used in Neurological Treatment:
Due to its potent MAO inhibitory properties, 3,5-Dichlorophenylhydrazine has potential applications in the treatment of depression and other neurological disorders, offering a pathway for developing new therapeutic approaches.

InChI:InChI=1/C6H6Cl2N2/c7-4-1-5(8)3-6(2-4)10-9/h1-3,10H,9H2

Upstream product

• 137273-10-0 N'-(3,5-Dichloro-phenyl)-hydrazinecarboxylic acid 2,2,2-trichloro-ethyl ester 
• 626-43-7 3,5-Dichloroaniline 
• 108-70-3 1,3,5-trichlorobenzene 

Downstream Products

• 4990-88-9 6-Chlor-6-desoxy-D-mannose-(3,5-dichlor-phenylhydrazon) 
• 96423-48-2 N-(3,5-Dichloro-phenyl)-N'-(4,5-dihydro-thiazol-2-yl)-hydrazine; hydrobromide 
• 96423-59-5 N-(3,5-Dichloro-phenyl)-N'-(5,6-dihydro-4H-[1,3]thiazin-2-yl)-hydrazine; hydrochloride 
• 77625-66-2 2-(3,5-Dichloro-phenyl)-1,4-dihydro-2H-thiochromeno[4,3-c]pyrazol-3-one 
• 73594-97-5 5-Amino-4-cyan-1-(3,5-dichlorphenyl)pyrazol 
• 76982-30-4 5-amino-1-(3,5-dichlorophenyl)-3-methyl-1H-pyrazole-4-carbonitrile 
• 176036-82-1 N-(3,5-dichlorophenyl)benzamide (3,5-dichlorophenyl)hydrazone 
• 96423-39-1 1-(3,5-Dichlor-phenyl)-thiosemicarbazid 
• 541-73-1 1,3-Dichlorobenzene 
• 76982-38-2 4-Amino-1-(3,5-dichlorphenyl)-3-methyl-1H-pyrazolo<3,4-d>pyrimidin 
• 135108-67-7 4-Amino-1-(3,5-dichloro-phenyl)-5-methyl-1,5-dihydro-pyrazolo[3,4-d]pyrimidin-6-one 
• 103855-01-2 ethyl 2-[2-(3,5-dichlorophenyl)hydrazinylidene]propanoate 
• 74478-58-3 phthalaldehydic acid phenylhydrazone 
• 588-64-7 (E)-1-benzylidene-2-phenylhydrazine 

Relevant articles and documents

Synthesis and biological evaluation of benzimidazole phenylhydrazone derivatives as antifungal agents against phytopathogenic fungi

A series of benzimidazole phenylhydrazone derivatives (6a-6ai) were synthesized and characterized by 1H-NMR, ESI-MS, and elemental analysis. The structure of 6b was further confirmed by single crystal X-ray diffraction as (E)-configuration. All the compounds were screened for antifungal activity against Rhizoctonia solani and Magnaporthe oryzae employing a mycelium growth rate method. Compound 6f exhibited significant inhibitory activity against R. solani and M. oryzae with the EC50 values of 1.20 and 1.85 μg/mL, respectively. In vivo testing demonstrated that 6f could effectively control the development of rice sheath blight (RSB) and rice blast (RB) caused by the above two phytopathogens. This work indicated that the compound 6f with a benzimidazole phenylhydrazone scaffold could be considered as a leading structure for the development of novel fungicides.

INDOLE CARBOXAMIDE DERIVATIVES AND USES THEREOF

A compound of Formula (I) is provided that has been shown to be useful for treating a disease, disorder or syndrome that is mediated by the transportation of essential molecules in the mmpL3 pathway: (I) wherein R1, R2, R3, R4, R5 and R6 are as defined herein.

Process for preparing pesticidal intermediates

The invention relates to processes for the preparation of compounds of formula (I) wherein R1and R2each independently represent a halogen atom.

Kinetics of the Alkaline Hydrolysis of several Alkyl Phenylcarbazates

The kinetics in 25percent (v/v) dioxane-water of the alkaline hydrolysis, followed by UV spectrometry, of several alkyl phenylcarbazates (Ar-NH-NHCOOR, with Ar = phenyl, 4-chlorophenyl, 4-fluorophenyl, 3,4-dichlorophenyl and R = methyl, ethyl, propyl, chloroethyl, trichloroethyl) are discussed.The pKa of trichloroethyl phenylcarbazate is 14.12 at 25 deg C.The pH profiles, the activation entropy of -40 cal mol-1 K-1, the kinetic solvent isotope effect, kOH-/kOD-, of 3.45, the general-base catalysis and the effect of the leaving group and of the substituent on the aromatic ring are in agreement with the involvement of a BAc2 reaction scheme.

Antiimplantation Agents: Part I - 1-Arylthiosemicarbazides

Several 1-arylthiosemicarbazides, 2-arylhydrazinothiazolines and 2-arylhydrazinodihydrothiazines have been examined for their antiimplantation activity in rats.Among the active compounds, 4-methyl-1-(3,5-bistrifluoromethylphenyl)thiosemicarbazide (3, C 2696-Go) and the corresponding 4,4-dimethyl (47), ethyl (4), n-butyl (5) and allyl (6) derivatives completely inhibit implantation at doses 10, 3, 20, 20 and 30 mg/kg respectively.The 3,4-dichlorophenyl analogue (32) is effective at a dose of 30 mg/kg. 2-(3,5-Bistrifluoromethylphenyl)hydrazinothiazoline (51) and the corresponding dihydrothiazine (63) show a weaker activity.The biological profile of C 2696-Go has been investigated in detail.It appears to prevent implantation by its antiuterotropic activity and ability to inhibit desiduoma formation.