399580-48-4 Usage
Uses
Used in Pharmaceutical Synthesis:
TFMPAA is used as a key intermediate in the synthesis of pharmaceutical compounds, leveraging its unique chemical properties to enhance the development of new drugs with improved efficacy and selectivity.
Used in Agrochemical Production:
In the agrochemical industry, TFMPAA serves as a crucial component in the creation of pesticides and other crop protection agents, contributing to the advancement of agricultural productivity and sustainability.
Used in Organic Synthesis:
As a reagent in organic synthesis, TFMPAA is instrumental in facilitating various chemical reactions, enabling the production of a wide array of organic molecules with diverse applications.
Used in Specialty Polymers and Advanced Materials:
TFMPAA is utilized as a precursor in the production of specialty polymers and other advanced materials, where its fluorinated nature imparts unique properties such as enhanced stability and reactivity, broadening the scope of material applications in various industries.
Check Digit Verification of cas no
The CAS Registry Mumber 399580-48-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,9,9,5,8 and 0 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 399580-48:
(8*3)+(7*9)+(6*9)+(5*5)+(4*8)+(3*0)+(2*4)+(1*8)=214
214 % 10 = 4
So 399580-48-4 is a valid CAS Registry Number.
399580-48-4Relevant articles and documents
Design, Synthesis, and Anticancer Activity of Cinnamoylated Barbituric Acid Derivatives
Liu, Yue,Li, Peng-Xiao,Mu, Wen-Wen,Sun, Ya-Lei,Liu, Ren-Min,Yang, Jie,Liu, Guo-Yun
, (2022/01/13)
This work deals with the design and synthesis of 18 barbituric acid derivatives bearing 1,3-dimethylbarbituric acid and cinnamic acid scaffolds to find potent anticancer agents. The target molecules were obtained through Knoevenagel condensation and acylation reaction. The cytotoxicity was assessed by the MTT assay. Flowcytometry was performed to determine the cell cycle arrest, apoptosis, ROS levels and the loss of MMP. The ratios of GSH/GSSG and the MDA levels were determined by using UV spectrophotometry. The results revealed that introducing substitutions (CF3, OCF3, F) on the meta- of the benzyl ring of barbituric acid derivatives led to a considerable increase in the antiproliferative activities compared with that of corresponding ortho- and para-substituted barbituric acid derivatives. Mechanism investigation implied that the 1c could increase the ROS and MDA level, decrease the ratio of GSH/GSSG and MMP, and lead to cell cycle arrest. Further research is needed for structural optimization to enhance hydrophilicity, thereby improve the biological activity of these compounds.
