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4-(TRIFLUOROMETHYL)-1,2-DIHYDRO-6-(4-METHOXYPHENYL)-2-THIOXOPYRIDINE-3-CARBONITRILE is a chemical with a specific purpose. Lookchem provides you with multiple data and supplier information of this chemical.

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  • 4-(TRIFLUOROMETHYL)-1,2-DIHYDRO-6-(4-METHOXYPHENYL)-2-THIOXOPYRIDINE-3-CARBONITRILE

    Cas No: 401649-63-6

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  • 401649-63-6 Structure
  • Basic information

    1. Product Name: 4-(TRIFLUOROMETHYL)-1,2-DIHYDRO-6-(4-METHOXYPHENYL)-2-THIOXOPYRIDINE-3-CARBONITRILE
    2. Synonyms: 4-(TRIFLUOROMETHYL)-1,2-DIHYDRO-6-(4-METHOXYPHENYL)-2-THIOXOPYRIDINE-3-CARBONITRILE;6-(4-METHOXYPHENYL)-2-THIOXO-4-(TRIFLUOROMETHYL)-1,2-DIHYDRO-3-PYRIDINECARBONITRILE;AKOS USSH-4110022;6-(4-methoxyphenyl)-2-sulfanylidene-4-(trifluoromethyl)-1,2-dihydropyridine-3-carbonitrile
    3. CAS NO:401649-63-6
    4. Molecular Formula: C14H9F3N2OS
    5. Molecular Weight: 310.29
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 401649-63-6.mol
  • Chemical Properties

    1. Melting Point: 215-217 °C(Solv: ethanol (64-17-5))
    2. Boiling Point: 354.2±52.0 °C(Predicted)
    3. Flash Point: N/A
    4. Appearance: /
    5. Density: 1.43±0.1 g/cm3(Predicted)
    6. Refractive Index: N/A
    7. Storage Temp.: N/A
    8. Solubility: N/A
    9. PKA: 5.88±0.70(Predicted)
    10. CAS DataBase Reference: 4-(TRIFLUOROMETHYL)-1,2-DIHYDRO-6-(4-METHOXYPHENYL)-2-THIOXOPYRIDINE-3-CARBONITRILE(CAS DataBase Reference)
    11. NIST Chemistry Reference: 4-(TRIFLUOROMETHYL)-1,2-DIHYDRO-6-(4-METHOXYPHENYL)-2-THIOXOPYRIDINE-3-CARBONITRILE(401649-63-6)
    12. EPA Substance Registry System: 4-(TRIFLUOROMETHYL)-1,2-DIHYDRO-6-(4-METHOXYPHENYL)-2-THIOXOPYRIDINE-3-CARBONITRILE(401649-63-6)
  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 401649-63-6(Hazardous Substances Data)

401649-63-6 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 401649-63-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 4,0,1,6,4 and 9 respectively; the second part has 2 digits, 6 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 401649-63:
(8*4)+(7*0)+(6*1)+(5*6)+(4*4)+(3*9)+(2*6)+(1*3)=126
126 % 10 = 6
So 401649-63-6 is a valid CAS Registry Number.

401649-63-6Downstream Products

401649-63-6Relevant articles and documents

Compound for targeted ubiquitination degradation of FoxM1 or pharmaceutically acceptable salt thereof, preparation method and application

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Paragraph 0065-0070, (2021/08/11)

The invention discloses a compound for targeted degradation of FoxM1 or a pharmaceutically acceptable salt thereof, a preparation method and application. The structure is shown as a general formula (I). Experimental results show that compared with a FoxM1 inhibitor FDI-6, the compound provided by the invention can effectively degrade a transcription factor FoxM1, especially a compound F-8, and shows relatively good anti-breast cancer activity in both cellular and animal levels.

Discovery and structure-activity relationships study of novel thieno[2,3-b]pyridine analogues as hepatitis C virus inhibitors

Wang, Ning-Yu,Zuo, Wei-Qiong,Xu, Ying,Gao, Chao,Zeng, Xiu-Xiu,Zhang, Li-Dan,You, Xin-Yu,Peng, Cui-Ting,Shen, Yang,Yang, Sheng-Yong,Wei, Yu-Quan,Yu, Luo-Ting

, p. 1581 - 1588 (2014/03/21)

Current treatment for hepatitis C is barely satisfactory, there is an urgent need to develop novel agents for combating hepatitis C virus infection. This study discovered a new class of thieno[2,3-b]pyridine derivatives as HCV inhibitors. First, a hit compound characterized by a thienopyridine core was identified in a cell-based screening of our privileged small molecule library. And then, structure activity relationship study of the hit compound led to the discovery of several potent compounds without obvious cytotoxicity in vitro (12c, EC50 = 3.3 μM, SI >30.3, 12b, EC50 = 3.5 μM, SI >28.6, 10l, EC50 = 3.9 μM, SI >25.6, 12o, EC 50 = 4.5 μM, SI >22.2, respectively). Although the mechanism of them had not been clearly elucidated, our preliminary optimization of this class of compounds had provided us a start point to develop new anti-HCV agents.

3-Amino-6-aryl(or 6-heteroaryl)-4-R2-thieno[2,3-b]pyridin-2-carboxylic acid amides, pharmaceutical compositions comprising the said and their use as inhibitors of TNFalpha release

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Page/Page column 19, (2008/06/13)

3-Amino-6-(hetero)aryl-thieno[2,3-b]pyridin-2-carboxylic acid amide derivatives (I) and their solvates, salts, prodrugs formulations, active metabolites or optionally tautomers are new. 3-Amino-6-(hetero)aryl-thieno[2,3-b]pyridin-2-carboxylic acid amide d

SUBSTITUTED PYRIDO[3',2':4,5]THIENO[3,2-D]PYRIMIDINE-2,4(1 H,3H)-DIONES AND -4(3H)-ONES, SUBSTITUTED THIENO[2,3-D:4,5-D']DIPYRIMIDINE-2,4(1 H,3H)-DIONES AND -4(3H)-ONES, SUBSTITUTED PYRIDO[3',2':4,5]FURO[3,2-D]PYRIMIDINE-2,4(1 H,3H)-DIONES AND -4(3H)-ONES, AND SUBSTITUTED FURO[2,3-D:4,5-D']DIPYRIMIDINE-2,4(1 H,3H)-DIONES AN

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Page/Page column 69, (2010/02/15)

The invention relates to novel pyrido[3',2':4,5]thieno[3,2-d]pyrimidine-2,4(1 H,3H)-diones and -4(3H)-one (X=C-H, Y=S), thieno[2,3-d:4,5-d']dipyrimidine-2,4(1 H,3H)-diones and -4(3H)-one (X=N, Y=S), in addition to pyrido[3',2':4,5]furo[3,2-d]pyrimidine-2,4(1 H,3H)-diones and -4(3H)-one (X=C-H, Y=0) and furo[2,3-d:4,5-d']dipyrimidine-2,4(1 H,3H)-diones and -4(3H)-one (X=N, Y=O) of general formulae 1a and 1b. The invention also relates to a method for the production thereof, pharmaceutical preparations containing said compounds and/or tautomers thereof and physiologically compatible salts which can be produced therefrom and/or solvates thereof, in addition to the pharmaceutical use of said compounds, tautomers thereof, salts or solvates, as inhibitors of TNFa-release.

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