A simple HPLC-UV method for the determination of dimenhydrinate and related substances - Identification of an unknown impurity
During the revision of the dimenhydrinate monograph of the European Pharmacopoeia a HPLC-UV method was developed. The procedure described allows a qualitative and quantitative determination of both dimenhydrinate compounds and of thirteen related substances. Furthermore a hitherto unknown impurity was identified and integrated into the purity check. Also 18 samples of dimenhydrinate have been tested. Thereby the relevant impurities of dimenhydrinate could be nominated and quantified.
Doege, Ulrica,Eger
p. 174 - 178
(2008/02/01)
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