Synthesis and biological activity of a novel class of small molecular weight peptidomimetic competitive inhibitors of protein tyrosine phosphatase 1B
Protein tyrosine phosphatase 1B (PTP1B) negatively regulates insulin signaling in part by dephosphorylating key tyrosine residues within the regulatory domain of the β-subunit of the insulin receptor (IR), thereby attenuating receptor tyrosine kinase acti
Larsen, Scott D.,Barf, Tjeerd,Liljebris, Charlotta,May, Paul D.,Ogg, Derek,O'Sullivan, Theresa J.,Palazuk, Barbara J.,Schostarez, Heinrich J.,Stevens, F. Craig,Bleasdale, John E.
p. 598 - 622
(2007/10/03)
Inhibitors of protein tyrosine phosphatase
The present invention comprises small molecular weight, non-peptidic inhibitors of formula I and II of Protein Tyrosine Phosphatase 1 (PTP1) which are useful for the treatment and/or prevention of Non-Insulin Dependent Diabetes Mellitus (NIDDM).
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Page column 32
(2010/11/29)
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