- Palladium-catalysed synthesis of biaryl phosphines
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Monodentate, biphenyl-type phosphines have emerged as a powerful class of ligands in homogeneous catalysis. Synthetic methods for these ligands are limited, however. We report that the palladium-catalysed Suzuki coupling of OPR2(o-C6H4X) (R=Ph, t-Bu; X=Br, I) with arylboronic acids affords a variety of biaryl phosphine oxides including those that contain heterocycles. The corresponding phosphines are readily obtained by treatment with HSiCl3. The methodology provides an easy entry to monodentate biaryl and heterobiaryl Poverlapping logical AND signX (X=N, O, S) phosphines with diverse steric and electronic properties.
- Baillie, Colin,Xiao, Jianliang
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p. 4159 - 4168
(2007/10/03)
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- Synthesis of biphenyl-based phosphines by Suzuki coupling
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A series of phosphine oxides has been synthesised by the palladium-catalysed Suzuki coupling of arylboronic acids with OPPh2(o-C6H4Br). On reduction with trichlorosilane, functionalised, biphenyl-based phosphine ligands were obtained in good yields. Our preliminary results indicate these ligands to be effective for palladium-catalysed C-C coupling reactions including the formation of their own oxides.
- Baillie, Colin,Chen, Weiping,Xiao, Jianliang
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p. 9085 - 9088
(2007/10/03)
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