Efficient dibenzo[c]acridine helicene-like synthesis and resolution: Scaleup, structural control, and high chiroptical properties
Herein, we describe our recent expeditious synthesis of dibenzo[c]acridine helicene-like compounds on a large scale in pure enantiomeric form. This flexible synthesis allows for variation at several positions on the skeleton. Geometrical parameters related to these compounds have been obtained from monocrystal X-ray structure resolution. Additionally, chiroptical parameters have been recorded, highlighting the versatility of this family showing for example optical rotation at 589 nm varying between 135 and 150 deg g -1cm2.
Jierry, Loic,Harthong, Steven,Aronica, Christophe,Mulatier, Jean-Christophe,Guy, Laure,Guy, Stephan