Design and Synthesis of α-Aryloxy-α-methylhydrocinnamic Acids: A Novel Class of Dual Peroxisome Proliferator-Activated Receptor α/ γ Agonists
The design and synthesis of the dual peroxisome proliferator activated receptor (PPAR) α/γ agonist (S)-2-methyl-3-{4-[2-(5-methyl-2-thiophen-2-yl-oxazol-4-yl)ethoxy]phenyl} -2-phenoxypropionic acid (2) for the treatment of type 2 diabetes and associated d
Xu, Yanping,Rito, Christopher J.,Etgen, Garret J.,Ardecky, Robert J.,Bean, James S.,Bensch, William R.,Bosley, Jacob R.,Broderick, Carol L.,Brooks, Dawn A.,Dominianni, Samuel J.,Hahn, Patric J.,Liu, Sha,Mais, Dale E.,Montrose-Rafizadeh, Chahrzad,Ogilvie, Kathy M.,Oldham, Brian A.,Peters, Mary,Rungta, Deepa K.,Shuker, Anthony J.,Stephenson, Gregory A.,Tripp, Allie E.,Wilson, Sarah B.,Winneroski, Leonard L.,Zink, Richard,Kauffman, Raymond F.,McCarthy, James R.