404921-35-3

Basic information

• Product Name: 9-(4-chlorophenyl)-10-(4-methoxyphenyl)-3,3,6,6-tetramethyl-3,4,6,7,9,10-hexahydro-1,8(2H,5H)-acridinedione
• Synonyms: 9-(4-chlorophenyl)-10-(4-methoxyphenyl)-3,3,6,6-tetramethyl-3,4,6,7,9,10-hexahydro-1,8(2H,5H)-acridinedione
• CAS NO: 404921-35-3
• Molecular Formula: C₃₀H₃₂ClNO₃
• Molecular Weight: 490.03298
• Mol File: 404921-35-3.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 9-(4-chlorophenyl)-10-(4-methoxyphenyl)-3,3,6,6-tetramethyl-3,4,6,7,9,10-hexahydro-1,8(2H,5H)-acridinedione(CAS DataBase Reference)
• NIST Chemistry Reference: 9-(4-chlorophenyl)-10-(4-methoxyphenyl)-3,3,6,6-tetramethyl-3,4,6,7,9,10-hexahydro-1,8(2H,5H)-acridinedione(404921-35-3)
• EPA Substance Registry System: 9-(4-chlorophenyl)-10-(4-methoxyphenyl)-3,3,6,6-tetramethyl-3,4,6,7,9,10-hexahydro-1,8(2H,5H)-acridinedione(404921-35-3)

Safety Data

• Hazardous Substances Data: 404921-35-3(Hazardous Substances Data)

Upstream product

• 104-88-1 4-chlorobenzaldehyde 
• 126-81-8 dimedone 
• 104-94-9 4-methoxy-aniline 
• 24706-48-7 3-[(4-methoxyphenyl)amino]-5,5-dimethylcyclohex-2-en-1-one 

Relevant articles and documents

Immobilization of organofunctionalized silica (SiMPTMS) with biphenyl-2,2′-dioic acid and investigation of its catalytic property for one-pot tandem synthesis of acridine-1,8-dione derivatives

Abstract: MPTMS-functionalized silica immobilized with biphenyl-2,2′-dioic acid, an efficient heterogeneous catalyst, was synthesized and characterized by various spectroscopic techniques such as FTIR, TGA, TEM and SEM. The catalytic activity of the synth

Magnetic nanoparticles grafted l-carnosine dipeptide: remarkable catalytic activity in water at room temperature

Modification of magnetic nanoparticle surface with l-carnosine dipeptide was developed using a simple chemical process. In order to synthesize this catalyst system, first, magnetic nanoparticles were modified with vinyl groups using trimethoxy(vinyl)silan

Baker’s yeast: An efficient, green, and reusable biocatalyst for the one-pot synthesis of biologically important N-substituted decahydroacridine-1,8-dione derivatives

A green approach for one-pot three-component synthesis of N-substituted decahydroacridine-1,8-diones is offered for the first time using baker’s yeast (Saccharomyces cerevisiae) as a biocatalyst under ultrasonication. Due to growing safety and environment

The synthesis of new 8-imino-1-one acridine derivatives catalyzed by a calix[4]arene mono-acid core

Mono-acid incorporated calix[4]arene has been successfully established as the catalyst for the synthesis of 8-imino-1-one acridine derivatives obtained by the condensation of enaminoketones and aldehydes (2:1 ratio). In this paper, we report the synthesis

Synthesis of 1,8-dioxo-decahydroacridines using pyridinium hydrogen sulfate ionic liquid as a green, efficient and reusable catalyst

Background: In this research, pyridinium hydrogen sulfate ionic liquid (PHSIL) was employed as a green, efficient and reusable catalyst for the synthesis of 1,8-dioxo-decahydroacridines. Different primary amines and aromatic aldehydes were subjected to the reaction with 5,5-dimethyl- 1,3-cyclohexanedione (dimedone) in the presence of this catalyst and the corresponding products were achieved in excellent yields and short reaction times. Two important advantages of the study were easily separation of ionic liquid from the reaction mixture by water extraction and a high recycling capability of up to six times. Methods: Different primary amines and aromatic aldehydes were subjected to the reaction with 5,5-dimethyl-1,3- cyclohexanedione (dimedone) in the presence of, pyridinium hydrogen sulfate ionic liquid (PHSIL) catalyst and the corresponding 1,8-dioxo-decahydroacridines derivatives were achieved in excellent yields and short reaction times. Results: Having established optimum conditions as follows: aldehyde (1 mmol), amine (1 mmol), PHSIL (0.65 mmol), CH3CN (3 mL) at 80°C, a series of 1,8-dioxo-decahydroacridines were synthesized via the one-pot three component reaction between various aromatic aldehydes and amines with dimedone. The aromatic aldehydes containing electrondonating and electron-withdrawing groups afforded 1,8-dioxo-9-aryl-10-aryl-decahydroacridines with high yields within short reaction times in comparison with other conventional procedures. The presence of substituent on the amine has the same effect. All compounds were identified by melting point (in some cases), IR spectra, 1H- and 13C-NMR and elemental analysis. Conclusion: In summary, pyridinium hydrogen sulfate ionic liquid was used as a green catalyst for the synthesize of 1,8- dioxo-decahydroacridines. Various derivatives of acridinediones were synthesized in high yield. Short-time reaction, high yield, stability, reusability up to six times, relatively non-toxicity of the catalyst, economically viable and one-pot synthesis of acridinedione derivatives are the important advantages of the reported method.

Ultrasound assisted multicomponent reactions: A green method for the synthesis of N-substituted 1,8-dioxo-decahydroacridines using β-cyclodextrin as a supramolecular reusable catalyst in water

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Acetic acid as an efficient catalyst for synthesis of 1,8-dioxo-octahydroxanthenes and 1,8-dioxo-decahydroacridines

1,8-Dioxo-octahydroxanthenes have been synthesized in good yields by reaction of arylaldehydes and dimedone in the presence of a catalytic amount of acetic acid, without use of any additional co-catalyst, under solvent-free, thermal conditions. We also re

Saccharose as a new, natural, and highly efficient catalyst for the one-pot synthesis of 4,5-dihydropyrano[3,2-c]chromenes, 2-amino-3-cyano-4H-chromenes, 1,8-dioxodecahydroacridine, and 2-substituted benzimidazole derivatives

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