405275-16-3

Basic information

• Product Name: (3-CHLORO-PHENYL)-(1H-INDOL-3-YL)-METHANONE
• Synonyms: (3-CHLORO-PHENYL)-(1H-INDOL-3-YL)-METHANONE;3-(3-Chlorobenzoyl)indole
• CAS NO: 405275-16-3
• Molecular Formula: C15H10ClNO
• Molecular Weight: 255.7
• Mol File: 405275-16-3.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: (3-CHLORO-PHENYL)-(1H-INDOL-3-YL)-METHANONE(CAS DataBase Reference)
• NIST Chemistry Reference: (3-CHLORO-PHENYL)-(1H-INDOL-3-YL)-METHANONE(405275-16-3)
• EPA Substance Registry System: (3-CHLORO-PHENYL)-(1H-INDOL-3-YL)-METHANONE(405275-16-3)

Safety Data

• Hazardous Substances Data: 405275-16-3(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(3-CHLORO-PHENYL)-(1H-INDOL-3-YL)-METHANONE is used as a building block for the synthesis of various pharmaceuticals due to its unique structural features. It contributes to the development of new drugs and enhances the therapeutic potential of existing ones.
Used in Medicinal Chemistry Research:
In the field of medicinal chemistry, (3-CHLORO-PHENYL)-(1H-INDOL-3-YL)-METHANONE serves as a key molecule for research. Its potential biological activities and therapeutic applications are being explored to advance the understanding of its role in drug discovery and design.

Upstream product

• 120-72-9 indole 
• 618-46-2 m-Chlorobenzoyl chloride 
• 26767-07-7 2-(3-chlorophenyl)-2-oxoacetic acid 

Relevant articles and documents

Synthesis of 3-aroylindoles as intermediates of cannabimimetics and elucidation of their physicochemical properties

In order to synthesize the intermediates of cannabimimetics, the benzoylation of indoles with 2'/3'/4'-substituted benzoyl chloride in the presence of Et2AlCl was examined. Among the products, we found that the1H NMR spectra of 3-(2'-substitute

Decarboxylative/decarbonylative C3-acylation of indoles: Via photocatalysis: A simple and efficient route to 3-acylindoles

A simple and efficient strategy for the preparation of 3-acylindoles via visible-light promoted C3-acylation of free (NH)- and N-substituted indoles with α-oxocarboxylic acids was developed. The reaction tolerates a wide range of functional groups, and the corresponding 3-acylindoles were obtained in high yields under mild conditions.

Collective Synthesis of 3-Acylindoles, Indole-3-carboxylic Esters, Indole-3-sulfinic Acids, and 3-(Methylsulfonyl)indoles from Free (N-H) Indoles via Common N-Indolyl Triethylborate

A general and direct C3 functionalization of free (N-H) indoles with readily available electrophiles such as acid chlorides, chloroformates, thionyl chloride, and methylsulfonyl chloride via a common N-indolyl triethylborate intermediate is reported. The reaction proceeds smoothly under mild conditions in up to 93% yield. Indoles with substituents at the C2, C4, C5, C6, and C7 positions are well tolerated. The easy accessibility of a variety of important 3-acylindoles, indole-3-carboxylic esters, indole-3-sulfinic acids, and 3-(methylsulfonyl)indoles demonstrates the high degree of compatibility and practicability of this method.

Antifungal and/or antiparasitic pharmaceutical composition and novel indole derivatives as active principle of such a composition

The present invention relates to novel indole derivatives, their method of preparation and their pharmacological activity as antimycotic and/or antiparasitic compounds.