405921-35-9

Basic information

• Product Name: 5-(2,5-dichlorobenzyl)-1,3-thiazol-2-amine
• Synonyms: 5-(2,5-dichlorobenzyl)-1,3-thiazol-2-amine;5-(2,5-dichlorobenzyl)thiazol-2-amine;5-[(2,5-dichlorophenyl)methyl]-1,3-thiazol-2-amine
• CAS NO: 405921-35-9
• Molecular Formula: C₁₀H₈Cl₂N₂S
• Molecular Weight: 259.15
• Mol File: 405921-35-9.mol

Chemical Properties

• Boiling Point: 403.5°C at 760 mmHg
• Flash Point: 197.8°C
• Appearance: /
• Density: 1.458g/cm³
• Vapor Pressure: 1.01E-06mmHg at 25°C
• Refractive Index: 1.665
• CAS DataBase Reference: 5-(2,5-dichlorobenzyl)-1,3-thiazol-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 5-(2,5-dichlorobenzyl)-1,3-thiazol-2-amine(405921-35-9)
• EPA Substance Registry System: 5-(2,5-dichlorobenzyl)-1,3-thiazol-2-amine(405921-35-9)

Safety Data

• Hazardous Substances Data: 405921-35-9(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H8Cl2N2S/c11-7-1-2-9(12)6(3-7)4-8-5-14-10(13)15-8/h1-3,5H,4H2,(H2,13,14)

Upstream product

• 17356-08-0 thiourea 
• 807667-34-1 2-chloro-3-(2,5-dichloro-phenyl)-propionaldehyde 
• 1057670-83-3 C₉H₈Cl₂O 
• 120-28-5 2,5-dichlorophenyl-diazonium chloride 

Downstream Products

• 1081314-14-8 C₂₅H₂₆Cl₂N₂O₅S 

Relevant articles and documents

Novel and potent inhibitors of stearoyl-CoA desaturase-1. Part I: Discovery of 3-(2-hydroxyethoxy)-4-methoxy-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamide

A series of structurally novel stearoyl-CoA desaturase-1 (SCD-1) inhibitors has been identified by optimizing a hit from our corporate library. Preliminary structure-activity relationship (SAR) studies led to the discovery of the highly potent and orally bioavailable thiazole-based SCD-1 inhibitor, 3-(2-hydroxyethoxy)-4-methoxy-N-[5-(3-trifluoromethylbenzyl)thiazol-2-yl]benzamide (23a).

Heterocyclic syntheses on the basis of arylation products of unsaturated compounds: X. 3-aryl-2-chloropropanals as reagents for the synthesis of 2-amino-1,3-thiazole derivatives

Meerwein reaction of arenediazonium chlorides with acrolein gave 3-aryl-2-chloropropanals which were brought into cyclocondensation with thiourea. The resulting 2-amino-5-benzyl-1,3-thiazoles were acylated with carboxylic acid chlorides and phthalic anhydride to afford, respectively, 2-acylamino-5-benzyl-1,3-thiazoles and N-(5-benzyl-1,3-thiazol-2-yl) phthalimides.