406720-50-1Relevant articles and documents
Mild deprotection of the: N-tert -butyloxycarbonyl (N -Boc) group using oxalyl chloride
Awuah, Samuel G.,George, Nathaniel,Ofori, Samuel,Parkin, Sean
, p. 24017 - 24026 (2020/07/23)
We report a mild method for the selective deprotection of the N-Boc group from a structurally diverse set of compounds, encompassing aliphatic, aromatic, and heterocyclic substrates by using oxalyl chloride in methanol. The reactions take place under room temperature conditions for 1-4 h with yields up to 90percent. This mild procedure was applied to a hybrid, medicinally active compound FC1, which is a novel dual inhibitor of IDO1 and DNA Pol gamma. A broader mechanism involving the electrophilic character of oxalyl chloride is postulated for this deprotection strategy. This journal is
Cyclization-carbonylation-cyclization coupling reactions of N-propargylanilines and o-alkynylphenols with palladium(II)-bisoxazoline catalysts
Kusakabe, Taichi,Sekiyama, Emika,Ishino, Yukari,Motodate, Satoshi,Kato, Shigeki,Mochida, Tomoyuki,Kato, Keisuke
supporting information; experimental part, p. 1825 - 1832 (2012/07/30)
Cyclization-carbonylation-cyclization coupling reactions (CCC-coupling reactions) of N-propargylanilines and o-alkynylphenols catalyzed by (box)Pd(II) complexes afforded symmetrical bis(quinolin-3-yl) and bis(benzofuran-3-yl) ketones, respectively, in mod
The scope and limitations of deuteration mediated by Crabtree's catalyst
Ellames, George J,Gibson, Jennifer S,Herbert, John M,McNeill, Alan H
, p. 9487 - 9497 (2007/10/03)
Exchange of protons for deuterons mediated by Crabtree's catalyst, 1, is directed efficiently by a functional group containing an sp2-hybridised nitrogen or oxygen atom; more electron-rich substrates are, in general, deuterated more efficiently. The electronic effects of substituents in the arene ring are critical only where the directing group is poor, in which case exchange is generally promoted by electron donating substituents, but the exchange is impeded by bulky meta-substituents.