- High Oxidizing Activity of 3,10-Dimethyl-8-azaisoalloxazine (8-Azaflavin) and its Synthetic Application as a Turnover Redox Catalyst under Aerobic Conditions
-
8-Azaflavin (1) has been synthesized, and its oxidizing activity has been examined kinetically for the oxidation of N-benzyl-1,4-dihydronicotinamide (BNAH), thiols, and nitroalkanes in aqueous solution under anaerobic conditions, by means of a comparison with 3,10-dimethylisoalloxazine (2).It was found that (1) is much more reactive than (2), 41-fold for BNAH, and 1E4-1E6-fold for thiols; (1) can be used as a turnover oxidation-reduction catalyst for disulphide and aldehyde syntheses in aqueous solution under aerobic conditions.The hydrolysis of (1) and the reducing activity of the reduced (1) have been briefly examined.
- Yano, Yumihiko,Ohshima, Masashi,Yatsu, Isao,Sutoh, Susumu,Vasquez, Rafael E.,et al.
-
p. 753 - 758
(2007/10/02)
-