40753-14-8

Basic information

• Product Name: 4-(4-METHYLPHENYL)-1,2,3-THIADIAZOLE
• Synonyms: BUTTPARK 33\06-72;4-(4-METHYLPHENYL)-1,2,3-THIADIAZOLE
• CAS NO: 40753-14-8
• Molecular Formula: C₉H₈N₂S
• Molecular Weight: 176.24
• Mol File: 40753-14-8.mol

Chemical Properties

• Melting Point: 73 °C
• Boiling Point: 299.9°C at 760 mmHg
• Flash Point: 133.3°C
• Appearance: /
• Density: 1.199g/cm³
• Vapor Pressure: 0.00206mmHg at 25°C
• Refractive Index: 1.599
• CAS DataBase Reference: 4-(4-METHYLPHENYL)-1,2,3-THIADIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(4-METHYLPHENYL)-1,2,3-THIADIAZOLE(40753-14-8)
• EPA Substance Registry System: 4-(4-METHYLPHENYL)-1,2,3-THIADIAZOLE(40753-14-8)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 40753-14-8(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
4-(4-METHYLPHENYL)-1,2,3-THIADIAZOLE is used as a key intermediate in the synthesis of pharmaceutical compounds for its potential biological activity. Its unique structure allows for the development of new drugs with therapeutic properties.
Used in Agrochemical Industry:
In the agrochemical field, 4-(4-METHYLPHENYL)-1,2,3-THIADIAZOLE is utilized as a building block for the creation of agrochemicals, such as pesticides and herbicides, due to its potential to enhance the effectiveness of these products.
Used in Materials Science:
4-(4-METHYLPHENYL)-1,2,3-THIADIAZOLE is employed in materials science for the development of new materials with specific properties. Its unique structure contributes to the creation of materials with potential applications in various industries.
Further research and exploration of 4-(4-METHYLPHENYL)-1,2,3-THIADIAZOLE's potential applications are ongoing, indicating its significance in the scientific community for future advancements in these fields.

InChI:InChI=1/C9H8N2S/c1-7-2-4-8(5-3-7)9-6-12-11-10-9/h2-6H,1H3

Upstream product

• 122-00-9 para-methylacetophenone 
• 1277181-63-1 2-[(Z)-2-[2-[(Z)-2-(aminocarbonyl)hydrazono]-2-(4-methylphenyl)ethyl]disulfanyl-1-(4-methylphenyl)ethylidene]-1-hydrazinecarboxamide 
• 1402671-88-8 C₁₈H₂₇N₄O₂S⁽¹⁺⁾*CF₃O₃S^(1-) 
• 1373121-46-0 N′-(2-bromo-1-(p-tolyl)ethylidene)benzohydrazide 
• 4209-24-9 p-methylphenacyl chloride 
• 60672-33-5 4-methyl-N'-(1-(p-tolyl)ethylidene)benzenesulfonohydrazide 
• 120445-91-2 1-p-tolyl-ethanone-E-semicarbazone 
• 55508-85-5 N-ethoxycarbonyl-(4-methylacetophenone)hydrazone 

Downstream Products

• 150398-92-8 (E)-thiokohlensaeure-O-ethyl-S-<2-(p-tolyl)ethenyl>-diester 
• 93515-89-0 [4-p-Tolyl-[1,3]dithiol-(2Z)-ylidene]-carbamic acid ethyl ester 
• 93515-86-7 N-[4-p-Tolyl-[1,3]dithiol-(2Z)-ylidene]-benzamide 
• 93515-88-9 N-[4-p-Tolyl-[1,3]dithiol-(2Z)-ylidene]-acetamide 
• 93515-87-8 4-Methyl-N-[4-p-tolyl-[1,3]dithiol-(2Z)-ylidene]-benzamide 
• 93515-64-1 potassium 2-p-tolylethynethiolate 
• 1001197-25-6 PPN[Au(p-CH₃-C₆H₄-CC-S)(C₆F₅)] 
• 1001197-20-1 [Au(p-CH₃-C₆H₄-CC-S)(PPh₃)] 
• 1001197-36-9 [Au(p-CH₃-C₆H₄-CC-S)(PPh₂Me)] 
• 1001197-27-8 [Au₂(p-CH₃-C₆H₄-CCS)2(1,2-bis(diphenylphosphino)ethane)] 
• 1001197-35-8 [Au(p-CH₃-C₆H₄-CC-S)(AsPh₃)] 

Relevant articles and documents

Synthesis method of 1, 2, 3-thiadiazole derivative

The invention belongs to the technical field of compound preparation, and discloses a synthesis method of a 1, 2, 3-thiadiazole derivative. The synthesis method of the 1, 2, 3-thiadiazole derivative comprises the following steps: taking an N-tosylhydrazon

Selective transformations of 2-(p-toluenesulfonyl)-N-tosylhydrazones to substituted 1,2,3-thiadiazoles

Selective transformations of 2-(p-toluenesulfonyl)-N-tosylhydrazones with different sulfur sources have been established. A series of 4-aryl-1,2,3-thiadiazoles and novel 4-aryl-5-tosyl-1,2,3-thiadiazoles were selectively constructed by the adjustment of reaction conditions. These protocols feature short reaction time, good compatibility of functional group, easily available materials, and good selectivity.

Diiiodine/Potassium Persulfate Mediated Synthesis of 1,2,3-Thiadiazoles from N -Tosylhydrazones and a Thiocyanate Salt as a Sulfur Source under Transition-Metal-Free Conditions

A highly efficient method for the synthesis of 1,2,3-thiadiazoles has been developed by utilizing readily available tosylhydrazones and ammonium thiocyanate with ecofriendly EtOH as the solvent at room temperature. The reaction shows a wide scope of subst

Perylenequinonoid-Catalyzed [4 + 1] and [4 + 2] Annulations of Azoalkenes: Photocatalytic Access to 1,2,3-Thiadiazole/1,4,5,6-Tetrahydropyridazine Derivatives

Nitrogen-containing heterocycles are especially considered "privileged" structural scaffolds for the development of new drugs. However, traditional methods of organic synthesis are mainly based on thermal cycloaddition reaction; thus, the exploration of n

Metal- and Oxidant-free Electrosynthesis of 1,2,3-Thiadiazoles from Element Sulfur and N-tosyl Hydrazones

A metal- and oxidant-free electrochemical method for synthesizing 1,2,3-thiadiazoles by inserting element sulfur into N-tosyl hydrazones is reported. This electrochemical transformation engages electrons as reagents to achieve redox processes, and avoid e

I2/CuCl2-promoted one-pot three-component synthesis of aliphatic or aromatic substituted 1,2,3-thiadiazoles

An efficient I2/CuCl2-promoted one-pot three-component strategy for the construction of 1,2,3-thiadiazoles from aliphatic- or aromatic-substituted methyl ketones, p-toluenesulfonyl hydrazide, and potassium thiocyanate has been develo

Preparation method of thiadiazole containing aryl group and alkyl group

The invention discloses a preparation method of thiadiazole containing an aryl group and an alkyl group. Methyl ketone, p-toluenesulfonhydrazide and potassium thiocyanate which are used as a substrateundergo a three-component one-pot reaction in DMSO used

Cascade Trisulfur Radical Anion (S3?-) Addition/Electron Detosylation Process for the Synthesis of 1,2,3-Thiadiazoles and Isothiazoles

Trisulfur radical anion (S3?-) mediated reactions with in situ formed azoalkenes and α,β-usaturated N-sulfonylimines for the construction of 1,2,3-thiadiazoles and isothiazoles has been developed. S3?- is in situ generated from potassium sulfide in DMF. These two approaches provide a new, safe, and simple way to construct 4-subsituted 1,2,3-thiadiazoles, 5-subsituted 1,2,3-thiadiazoles, and isothiazole in good yields. The reactions include the formation of the new C-S and N-S bonds via S3?- addition and electron detosylation under mild conditions.

Coupled Flavin-Iodine Redox Organocatalysts: Aerobic Oxidative Transformation from N-Tosylhydrazones to 1,2,3-Thiadiazoles

A bioinspired two-component redox organocatalyst system using 1,10-bridged flavinium and NH4I was developed to perform environmentally friendly aerobic oxidative ring formation of 1,2,3-thiadiazoles from N-tosylhydrazones and sulfur. The redox

Stereochemistry and mechanistic insights in the [2t + 2i + 2i] annulations of thioketenes and imines

Stereochemical models and mechanistic insights are proposed for [2t + 2i + 2i] annulations of thioketenes and imines on the basis of experimental and computational investigations. In the [2t + 2i + 2