New enediyne derivatives: Synthesis of symmetrically and unsymmetrically disubstituted 4,5-dialkynyl-3(2H)-pyridazinones
4,5-Dialkynyl-2-(methyl or phenyl)-3(2H)-pyridazinones (2a-c) were efficiently prepared via Sonogashira cross-coupling reaction on 4,5-dichloro-2-(methyl or phenyl)-3(2H)-pyridazinones (1a,b). Selective Sonogashira reactions were successfully achieved on
R'kyek, Omar,Maes, Bert U.W,Jonckers, Tim H.M,Lemière, Guy L.F,Dommisse, Roger A
p. 10009 - 10016
(2007/10/03)
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