- Synthesis and biology of the rigidified glutamate analogue, trans-2-carboxyazetidine-3-acetic acid (t-CAA)
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Chemical approaches to the (-)- and (+)-trans-2-carboxyazetidine-3-acetic acids (-)-1 and (+)-1, and their homologues (-)-2 and (+)-2, compounds that represent rigidified analogues of glutamate (glu), are reported together with the complete biological characterization of (+)-1 (t-CAA) at the known glu recognition sites. t-CAA was found to be an inhibitor of Na+-dependent glu uptake and to act as a kainate receptor ligand.
- Kozikowski, Alan P.,Liao, Yi,Tueckmantel, Werner,Wang, Shaomeng,Pshenichkin, Sergey,Surin, Alexander,Thomsen, Christian,Wroblewski, Jarda T.
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p. 2559 - 2564
(2007/10/03)
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- 4-Substituted-2-azetidinone compound, process of producing the compounds, and medicaments containing the compounds
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A novel 4-substituted-2-azetidinone compound shown by the general formula STR1 and salts thereof. The compounds of this invention have a strong CNS activity and are useful for improving a disturbance of consciousness in schizophrenia, a head injury, etc., or improving hypobulia, memory loss, etc.
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