- Two triterpenyl fatty acid esters from fagonia cretica as lipoxygenase inhibitors
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Two triterpenyl fatty acid esters were isolated from the chloroform soluble fraction of Fagonia cretica and their structures elucidated as 3β-12-ursen-3yl-docosanoate (1) and 3β-12-ursen-3yl-nonacosanoate (2) by 1D-NMR, 2D-NMR, mass spectrometric and chemical analyses. Both new compounds were also evaluated for their lipoxygenase inhibitory potential using Baicalein as a standard.
- Nawaz, Zahid,Ahmed, Ejaz,Sharif, Ahsan,Sajid, Anam,Arshed, Faiza,Arshad, Muhammad,Anjum, Muhammad Imran,Razaq, Abdul
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p. 406 - 409
(2018/06/06)
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- C-GLYCOLIPIDS WITH ENHANCED TH-1 PROFILE
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The invention is directed to novel synthetic C-glycolipids that selectively induce a ThI -type immune response characterized by enhanced IL- 12 secretion and increased activation of dendritic cells. The compounds of the invention are thereby useful in treating infections, cancers, cell proliferative disorders, and autoimmune diseases, both directly and as adjuvants.
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Page/Page column 37
(2008/06/13)
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- Synthesis of Very Long Fatty Acid Methyl Esters
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Phosphoranes, produced by treating alkyltriphenylphosphonium bromides with lithium hexamethyldisilazide, reacted with ω-oxo esters to give modest yields of the corresponding methyl cis-alkenoates.By an alternative method, treatment of ω-iodo esters with the complexes formed from reactions of alkylcopper(I) and Grignard reagents gave methyl alkanoates, cis-alkenoates, and methylene-interrupted cis,cis-alka-dienoates and cis,cis,cis-trienoates.The stereochemical integrity of the esters was determined by 13C NMR spectroscopy.
- Kling, Marcel R.,Easton, Christopher J.,Poulos, Alf
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p. 1183 - 1190
(2007/10/02)
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- A New Synthesis of Long Chain Acid Esters and Carbinols
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A versatile synthesis of difficulty accessible long chain acid esters and carbinols is described.The synthesis involves acylations at 2- and 5-positions of thiophene.Thioketalation of the resulting ketoesters followed by Raney nickel desulfurization yield acid esters which on LAH reduction give the corresponding carbinols.
- Rao, S. Jagadishwar,Bhalerao, U. T.,Tilak, B. D.
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p. 208 - 211
(2007/10/02)
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