The Chapman rearrangement in a continuous-flow microreactor
The Chapman rearrangement is of practical significance in pharmaceutical and fine chemical industries. It is a high temperature reaction with an exothermic nature in numerous cases. The conventional batch-wise synthesis is limited by its operational compl
Copper-catalyzed C-N cross-coupling of substituted 2-halobenzoates with secondary acyclic amides
The copper-catalyzed C-N cross-coupling of poorly nucleophilic acyclic secondary amides with sterically hindered substituted 2-halobenzoates has been demonstrated with 1,4-dimethyl-3,4-dihydro-1H-benzo[e][1,4]diazepin-5(2H)-one (DMBDO) as ligands for the first time. The protocol is effective for the synthesis of hindered tertiary amides. We also found that the alkoxycarbonyl (CO2R) group has a strong ortho-substituent effect on a Goldberg-type C-N coupling reaction. Georg Thieme Verlag Stuttgart. New York.
Wang, Man-Gang,Yu, Hua,Wu, Jun,Shang, Zhi-Cai
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p. 1955 - 1964
(2013/07/26)
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