- Preparation method of methyl 5-chloro-4-acetamido-2-methoxybenzoate
-
The invention discloses a preparation method of methyl 5-chloro-4-acetamido-2-methoxybenzoate, and belongs to the technical field of chemical synthesis, the preparation method comprises the following steps: dissolving 4-acetamido-2-methoxybenzoic acid methyl ester in N, N-dimethylformamide, adding N-chlorosuccinimide, carrying out a heat preservation reaction, obtaining a crude product of methyl 5-chloro-4-acetamido-2-methoxybenzoate, and then refining the crude product of methyl 5-chloro-4-acetamido-2-methoxybenzoate. A microporous filter membrane is used in the refining process, an antibacterial filler is prepared in the process of preparing the microporous filter membrane, the antibacterial filler can reduce the activity of metabolic enzymes in microbial cells so as to hinder the respiratory action of the microbial cells, and interferes the generation of substances required by bacterial production so that the phenomenon of mildew growth of the microporous filter membrane is prevented, antibacterial components in the microporous filter membrane cannot be lost after the microporous filter membrane is used for many times, and thus the microporous filter membrane still has a good antibacterial effect after being used for many times.
- -
-
Paragraph 0028-0030; 0038-0040; 0048-0050
(2021/08/11)
-
- As neuroprotective agents of pharmaceutical compounds
-
The invention discloses a medicinal compound as a neuroprotective agent. The medicinal compound is a neuronal nitric oxide synthase-postsynaptic density protein 95 (nNOS-PSD95) decoupling agent. The medicinal compound is a benzene ring derivative shown in the general formula (I) or its pharmaceutically acceptable salt. The invention further discloses a preparation method of the medicinal compound and a use of the medicinal compound in prevention and treatment on neuronal damage influence-caused diseases.
- -
-
-
- Preparation method of methyl 4-acetamido-5-chloro-2-methoxybenzoate
-
The invention relates to the technical field of chemical synthesis, and concretely relates to a preparation method of methyl 4-acetamido-5-chloro-2-methoxybenzoate. The method comprises the following steps: dissolving methyl 4-acetamido-2-methoxybenzoate in N,N-dimethyl formamide, adding N-chlorosuccimide, carrying out a heat insulation reaction to obtain crude methyl 4-acetamido-5-chloro-2-methoxybenzoate, separating out the crude methyl 4-acetamido-5-chloro-2-methoxybenzoate to obtain an N,N-dimethyl formamide mother liquor, and directly using the N,N-dimethyl formamide mother liquor as a solvent for preparing methyl 4-acetamido-5-chloro-2-methoxybenzoate without treatment. The preparation method has the advantages of high mole yield, low cost, safety and environmental protection.
- -
-
Paragraph 0029
(2016/11/14)
-
- Synthesis and biological evaluation of berberine derivatives as IBS modulator
-
Irritable bowel syndrome is the most common functional gastrointestinal disorder characterized by chronic abdominal pain or discomfort in association with a change in bowel habit. 5-HT receptor modulators have been developed as IBS therapeutic agents and proved to be effective in the treatment of the disease. In this letter, 12 berberine derivatives were designed and synthesized as 5-HT receptor modulators. Preliminary biological tests suggested that the new compounds exhibited promising activity for IBS therapy.
- Deng, Xin,Zhao, Xinxin,Han, Jing,Wang, Jingjie,Huang, Wenlong,Qian, Hai,Ge, Liang
-
scheme or table
p. 489 - 493
(2012/08/29)
-
- HETEROCYCLIC COMPOUNDS FOR THE INHIBITION OF PASK
-
Disclosed herein are new heterocyclic compounds and compositions and their application as pharmaceuticals for the treatment of disease. Methods of inhibiting PAS Kinase (PASK) activity in a human or animal subject are also provided for the treatment of diseases such as diabetes mellitus.
- -
-
Page/Page column 59
(2012/11/08)
-
- Highly selective C-H functionalization/halogenation of acetanilide
-
Highly regioselective C-H functionalization/halogenation of acetanilides to produce ortho-haloacetanilides was catalyzed by Pd(OAc)2 and Cu(OAc)2 with CuX2 as the halogen source. Copyright
- Wan, Xiaobing,Ma, Zhongxun,Li, Bijie,Zhang, Keya,Cao, Shaokui,Zhang, Shiwei,Shi, Zhangjie
-
p. 7416 - 7417
(2007/10/04)
-
- Alternative heterocycles for DNA recognition
-
Methods and compositions are provided for forming complexes between dsDNA and novel oligomers comprising fused six-membered rings. By appropriate choice of target sequences and oligomers, complexes comprising oligomer-DNA are obtained with high association constants. The formation of complexes can be used for identification of specific dsDNA sequences, for inhibiting gene transcription, and as a therapeutic for inhibiting proliferation of undesired cells or modulation of expression of specific genes.
- -
-
-
- Dibenzofurancarboxamides and their pharmaceutical compositions and methods
-
This invention is directed to certain dibenzofurancarboxamides and their use as 5HT3 antagonists having unique CNS, anti-emetic and gastric prokinetic activity void of any significant D2 receptor binding properties. This invention also describes novel processes necessary for their preparation.
- -
-
-
- Aromatic amides of heterocyclic compounds and therapeutic compositions containing same
-
The invention relates to aromatic amides N-substituted by heterocyclic groups. More particularly, the invention relates to substituted benzoic acid amides of 1-arylalkylamino or aminoalkyl-N-heterocyclic rings and to pharmaceutical compositions thereof, which have the ability to antagonize the effects of dopamine or dopaminergic agents of endogenous or exogenous origin and which may be used for the treatment of nausea and vomiting resulting from gastrointestinal disorders, congestive heart failure, post operative conditions, etc., other gastrointestinal disorders such as dyspepsia, flatulence, bile regurgitations, hiatus hernia, peptic ulcer, reflux aerophagitis, gastritis, duodenitis, and cholethiasis, and a variety of conditions affecting the central nervous system such as acute and chronic psychoses, maniacal psychosis, schizophrenias, serious disturbances of behavior and non-melancholic depressive state and migraine.
- -
-
-