- FAP-Activated Proteasome Inhibitors for Treating Solid Tumors
-
Disclosed are proteasome inhibitors, fibroblast activation protein (FAP)-activated prodrugs of proteasome inhibitors, and pharmaceutically acceptable salts of the inhibitors and prodrugs. Also disclosed are related pharmaceutical compositions, and methods
- -
-
Page/Page column 0022; 0310
(2016/12/22)
-
- FAP-ACTIVATED THERAPEUTIC AGENTS, AND USES RELATED THERETO
-
Disclosed are prodrugs of cytotoxic anthracyclines (such as doxorubicin) and other therapeutic agents that are selectively cleaved and activated by fibroblast activating protein (FAP). The prodrugs are useful for targeted delivery of cytotoxic and other agents to FAP- expressing tissues, including cancer (e.g., solid tumors). Also provided are pharmaceutical compounds comprising the prodrugs, as well as methods of using the prodrugs to treat a disorder characterized by FAP upregulation, e.g., cancer, fibrosis, and inflammation.
- -
-
-
- Investigation of the active turn geometry for the labour delaying activity of indolizidinone and azapeptide modulators of the prostaglandin F2α receptor
-
On pursuing molecules that delay labour, so-called tocolytics, the prostaglandin F2α receptor (FP) was targeted, because of its role in the stimulation of uterine contractions leading to birth and preterm birth. Previously, both the indolizidin
- Boukanoun, Meriem K.,Hou, Xin,Nikolajev, Ljiljana,Ratni, Sara,Olson, David,Claing, Audrey,Laporte, Stéphane A.,Chemtob, Sylvain,Lubell, William D.
-
p. 7750 - 7761
(2015/07/15)
-
- FAP-ACTIVATED PROTEASOME INHIBITORS FOR TREATING SOLID TUMORS
-
Disclosed are proteasome inhibitors, FAP-activated prodrugs of proteasome inhibitors, and pharmaceutically acceptable salts of the inhibitors and prodrugs. Also disclosed are related pharmaceutical compositions, and methods of using the inhibitors and pro
- -
-
Page/Page column 39
(2013/03/28)
-