A series of 5-aminosubstituted 4-fluorobenzyl-8-hydroxy-[1,6]naphthyridine-7-carboxamide HIV-1 integrase inhibitors
A series of 5-amino derivatives of 8-hydroxy[1,6]-naphthyridine-7-carboxamide exhibiting sub-micromolar potency against replication of HIV-1 in cell culture was identified. One of these analogs, compound 12, displayed excellent pharmacokinetic properties
Guare, James P.,Wai, John S.,Gomez, Robert P.,Anthony, Neville J.,Jolly, Samson M.,Cortes, Amanda R.,Vacca, Joseph P.,Felock, Peter J.,Stillmock, Kara A.,Schleif, William A.,Moyer, Gregory,Gabryelski, Lori J.,Jin, Lixia,Chen, I-Wu,Hazuda, Daria J.,Young, Steven D.
p. 2900 - 2904
(2008/09/20)
Aza- and polyaza-naphthalenyl carboxamides useful as HIV integrase inhibitors
Aza- and polyaza-naphthalenyl carboxamide derivatives including certain quinoline carboxamide and naphthyridine carboxamide derivatives are described. These compounds are inhibitors of HIV integrase and inhibitors of HIV replication, and are useful in the
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(2008/06/13)
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