- Sesquiterpene lactones and thymol esters from Vicoa pentanema
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The aerial parts of Vicoa pentanema yielded four new sesquiterpene lactones, namely, 10a-hydroxy- 14H-inuviscolide (1), 4α,5α-epoxy- 10α,11β,13H, 14H-1 -epi-inuviscolide 3-β-D-glucoside (2), 2α-O-acetyl- 3β-hydroxyalantolactone (3), and 2α,3α-dihydroxyalloalantolactone (4). The structure and stereochemical assignments of all sesquiterpenes were based on their 1H and 13C-NMR spectral data, including those derived from 2D-NMR COSY, HETCOR, FLOCK, and NOESY experiments, as well as extensive NOE- difference studies. In addition, the same plant material yielded the known sesquiterpene lactones 8β-hydroxyparthenolide (5), 8-epi-confertin (6), 4α,5α-epoxy-10α,14H-1-epi-inuviscolide (7), inuviscolide (8), lipiferolide (9), and carabrone (10), the known thymol ester 7,8-epoxy-9- (isobutyryloxy)thymolisobutyrate (11), and its hydrolysis product 7-hydroxy- 8,9-bis(isobutyryloxy)thymol (12).
- Mossa, Jaber S.,El-Feraly, Farouk S.,Muhammad, Ilias,Zaw, Kyaw,Mbwambo, Zakaria H.,Pezzuto, John M.,Fong, Harry H. S.
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