- Pyrazine associated novel 1,2,4-triazolo thiadazines: Synthesis, characterization and as antibacterial agents
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5-(5-Methyl-pyrazin-2-yl)-[1,3,4]-oxadiazole-2-thiol (4) has been synthesized form the starting material 5-methyl-2-pyrazinecarboxylic acid (1) on esterification with ethanol and condensation with hydrazine hydrate followed by cyclization with carbon disu
- Maddireddi, Chandra Sekhara Reddi,Parimi, Uma Devi,Reddy, Sreenivasa Reddy Bhimi,Mandapati, Satyanarayana Reddy
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p. 2453 - 2456
(2016/10/12)
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- Pharmaceutically acceptable inorganic and organic salts of 5-methylpyrazine-2-carboxylic acid-4-oxide
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Methods for the preparation of pharmaceutically acceptable organic or inorganic salts of 5-methylpyrazinecarboxylic acid-4-oxide esters including tris(hydroxymethyl)aminomethanol, N,N-dimethylethanolamine, N-methyl-D-glucamine, L-Lysine, L-arginine, Na, K, Ca and Mg. The esters of 5-methylpyrazinecarboxylic acid-4-oxide are oxidized in aqueous hydrogen peroxide at a pH of 2.5 to 7 in the presence of a catalyst selected from the group consisting of sodium tungstate, tungstic acid and ammonium heptamolybdate. The salts are formed by saponification of the esters followed by alcohol precipitation, or by reaction with a metal trimethylsilanoate, or by the reaction of organic bases with the saponified acids.
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Page/Page column 2
(2010/02/14)
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- Method for the preparation of 5-methylpyrazine-2-carboxylic acid-4-oxide and its salts
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Methods for the preparation of pharmaceutically acceptable salts of 5-methylpyrazine-carboxylic acid-4-oxide by using the oxidizing agent OXONE? for the N-oxidation of C1-4 methylpyrazinecarboxylic acid esters. The pharmaceutically acceptable salts are then formed by the saponification of the esters followed by alcohol precipitation.
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Page/Page column 2
(2008/06/13)
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- NOVEL BENSOPHENONE DERIVATIVES OR SALTS THEREOF
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A benzophenone derivative represented by the following formula: whereinR1 represents, for example, an optionally substituted heterocyclic group, or a substituted phenyl group; Z represents, for example, an alkylene group; R2 represents, for example, a carboxyl group optionally protected with alkyl;R3 represents, for example, an optionally protected hydroxyl group; R4 represents, for example, an optionally substituted cycloalkyloxy group; and R5 represents, for example, a hydrogen atom, ???or a salt thereof has anti-arthritic activity, inhibits bone destruction caused by arthritis, and provides high safety and excellent pharmacokinetics and thus is useful as therapeutic agent for arthritis. These compounds have inhibitory effect on AP-1 activity and are useful as preventive or therapeutic agent for diseases in which excessive expression of AP-1 is involved.
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Page 133-134
(2010/02/07)
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- CONDENSED HETEROCYCLIC COMPOUNDS AS CALCITONIN AGONISTS
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The present invention relates to novel fused heterocyclic ring system compounds and methods for their use in the treatment and prevention of diseases or conditions which are related to irregular calcification.
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Page/Page column 74-75
(2010/02/07)
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