41238-48-6Relevant articles and documents
The biosynthesis of the Streptomyces antibiotic bicyclomycin
Bradley, Emma L.,Herbert, Richard B.,Lawrie, Kenneth W.M.,Khan, Jeffrey A.,Moody, Claire M.,Young, Douglas W.
, p. 6935 - 6938 (2007/10/03)
Bicyclomycin 5 is biosynthesized in Streptomyces sapporonensis from L-leucine 2 and L-isoleucine 1 by way of the naturally occurring diketopiperazine 3 and dihydrobicyclomycin 4. The mode of incorporation of (2S,4R)-[5,5,5-2H3]leucine into 5 (and 4) shows that the entry of hydroxy group at C-2' occurs with unusual inversion of configuration. The results of inhibition studies permit a useful working hypothesis to be advanced for bicyclomycin biosynthesis.