- Derivatives of 9-oxo-13-trans-prostenoic acid esters
-
This disclosure describes homologues, analogues, congeners, and derivatives of 9-oxo-13-trans-prostenoic acid and of 9-hydroxy-13-trans-prostenoic acid, having antimicrobial activity and prostaglandin-like hypotensive activity.
- -
-
-
- 1-Alkoximino-2-(ω-substituted alkyl)-2-cyclopentenes
-
This disclosure describes certain 1-alkoximino-2-(ω-substituted-alkyl)-2-cyclopentenes useful as intermediates for the preparation of homologues, analogues, congeners, and derivatives of 9-oxo-13-trans-prostenoic acid and of 9-hydroxy-13-trans-prostenoic acid which have antimicrobial activity and prostaglandin-like hypotensive activity.
- -
-
-
- 11,15-DIHYDROXY-9-OXOPROST-13-YNOIC ACID
-
3-(Optionally oxygenated)-5-oxocyclopent-1-enealkanoic acids and their alkyl esters are allowed to react with appropriate alkenyl copper, alkenyl boron, alkynyl boron, alkynyl gallium or alkynyl aluminum compounds to produce the corresponding 2-(3-hydroxy-3-optionally alkylated!-1-alkenyl)cyclopentanealkanoic acids, 2-(3-hydroxy-3-optionally alkylated!-1-alkynyl)cyclopentanealkanoic acids and their esters. The prostaglandin derivatives so produced are valuable and useful as pharmacological agents as is evidenced by their central nervous system-affective, anti-bacterial, anti-fungal and prostaglandin antagonist activity.
- -
-
-
- Derivatives of 9-oxo-13-trans-prostenoic acid amides
-
This disclosure described homologues, analogues, congeners, and derivatives of 9-oxo-13-trans-prostenamide and of 9-hydroxy-13-trans-prostenamide, having antimicrobial activity and prostaglandin-like hypotensive activity.
- -
-
-
- Hydroxylated 15-deoxy derivatives of 9-hydroxy-13-trans-prostenoic acid
-
This disclosure describes certain 15-deoxy prostanoic acid derivatives having a hydroxy group further along in the beta-chain, useful as bronchodilators, hypotensive agents, anti-ulcer agents, or as intermediates.
- -
-
-