- Multiple regioselective functionalizations of quinolines via magnesiations
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A wide range of polyfunctionalized quinolines was prepared via chemo- and regioselective magnesiation reactions using appropriate Mg reagents, such as i-PrMgCl-LiCl, MesMgBr·LiCl, Mes2Mg·2LiBr, TMPMgCl·LiCl, and TMP2Mg·2LiCl. An application to the total synthesis of the biologically active compound talnetant was performed (six steps, 28%).
- Boudet, Nadege,Lachs, Jennifer R.,Knochel, Paul
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p. 5525 - 5528
(2008/09/17)
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