41743-44-6

Basic information

• Product Name: FERUTININ
• Synonyms: FERUTININ;TEFESTROL;Ferutinin (high purity);Ferutinol p-hydroxybenzoate;Jaeschkeanadiol p-hydroxybenzoate
• CAS NO: 41743-44-6
• Molecular Formula: C₂₂H₃₀O₄
• Molecular Weight: 358.47
• Mol File: 41743-44-6.mol

Chemical Properties

• Boiling Point: 489°C at 760 mmHg
• Flash Point: 164.4°C
• Appearance: /
• Density: 1.16g/cm³
• Vapor Pressure: 2.24E-10mmHg at 25°C
• Refractive Index: 1.573
• CAS DataBase Reference: FERUTININ(CAS DataBase Reference)
• NIST Chemistry Reference: FERUTININ(41743-44-6)
• EPA Substance Registry System: FERUTININ(41743-44-6)

Safety Data

• Hazardous Substances Data: 41743-44-6(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
FERUTININ is used as a pharmaceutical agent for its agonistic activity towards the estrogen receptor (ER) α. This property makes it potentially useful in the treatment of conditions related to estrogen deficiency or imbalance, such as menopausal symptoms, osteoporosis, and certain types of cancer.
Used in Cellular Research:
In cellular research, FERUTININ is used as a tool to study the effects of increased calcium permeability on various cellular structures, including mitochondria, thymocytes, sarcoplasmic reticulum, and liposomes. This can help researchers better understand the role of calcium in cellular processes and develop new therapeutic strategies for conditions involving calcium dysregulation.
Used in Drug Delivery Systems:
FERUTININ's ability to increase calcium permeability can be exploited in the development of novel drug delivery systems. By enhancing the permeability of cellular membranes, FERUTININ may facilitate the delivery of therapeutic agents into cells, potentially improving the efficacy and bioavailability of certain drugs.
Used in Cosmetics Industry:
In the cosmetics industry, FERUTININ may be used as an ingredient in anti-aging products due to its agonistic activity towards the estrogen receptor (ER) α. This could potentially help improve skin elasticity, reduce wrinkles, and provide other age-defying benefits.

InChI:InChI=1/C22H30O4/c1-14(2)22(25)12-11-21(4)10-9-15(3)13-18(19(21)22)26-20(24)16-5-7-17(23)8-6-16/h5-9,14,18-19,23,25H,10-13H2,1-4H3/t18-,19+,21-,22+/m0/s1

Upstream product

• 99-96-7 4-hydroxy-benzoic acid 
• 778584-24-0 3-hydroxy-3-isopropyl-6,8a-dimethyl-1,2,3,3a,4,5,8,8a-octahydroazulen-4-yl 4-(pivaloyloxy)benzoate 
• 41690-67-9 1-isopropyl-3a,6-dimethyl-1,2,3,3a,4,7,8,8a-octahydroazulene-1,8-diol 
• 27914-73-4 4-acetoxybenzoyl chloride 
• 152835-32-0 4β-hydroxy-6α-(4-acetoxybenzoyloxy)-8-daucene 

Downstream Products

• 778584-20-6 (8R,9S)-8,9-dihydro-8,9-dihydroxyferutinin 
• 1026606-77-8 4-acetoxy-benzoic acid 6-formyl-3-hydroxy-3-isopropyl-8a-methyl-1,2,3,3a,4,5,8,8a-octahydro-azulen-4-yl ester 
• 778584-21-7 (8R),9H-8,9-dihydro-8-hydroxy-9-oxoferutinin 
• 1027167-69-6 4-acetoxy-benzoic acid 3-hydroxy-6-hydroxymethyl-3-isopropyl-8a-methyl-1,2,3,3a,4,5,8,8a-octahydro-azulen-4-yl ester 
• 41690-67-9 1-isopropyl-3a,6-dimethyl-1,2,3,3a,4,7,8,8a-octahydroazulene-1,8-diol 

Relevant articles and documents

Hemisynthesis, Antitumoral Effect, and Molecular Docking Studies of Ferutinin and Its Analogues

The natural product ferutinin was shown to act as an agonist to estrogen receptor ERα and agonist/antagonist to ERβ featuring a weak antiproliferative activity toward breast cancer cells. To enhance this activity, ferutinin analogues were synthesized by e

PROSTANOIDS. LVIII. NEW α,ω-NORANALOGS OF PROSTAGLANDINS FROM FERUTINOL

The chemical transformations of ferutinol aimed at the construction of structures that are of pharmacological interest were studied.