- Three new neuritogenic steroidal saponins from Ophiopogon japonicus (Thunb.) Ker-Gawl
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Three new steroidal saponins (1-3) and a known saponin (4) were isolated from Ophiopogon japonicus (Thunb.) Ker-Gawl. Their structures were determined by spectroscopic analyses and chemical derivatization. The isolated compounds (1-4) were potent inducers of neuritogenesis on PC12 cells. Compound 1 showed the highest neuritogenic activity of 46% at 1 μM. The study of structure-activity relationships suggests that aglycone is important for the neuritogenic activity of the compounds. Specific inhibitor experiments and Western blot analysis suggest that 1-induced neuritogenic activity depends on the activation of mitogen-activated protein kinase kinase (MEK)/extracellular signal regulated kinase (ERK) signaling pathway on PC12 cells.
- Ye, Ying,Qu, Yuan,Tang, Ruiqi,Cao, Shining,Yang, Wei,Xiang, Lan,Qi, Jianhua
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p. 1171 - 1176
(2013/10/08)
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- Steroidal glycosides from the subterranean parts of Liriope spicata var. prolifera
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In a continuation of phytochemical studies on the underground organs of Liriope spicata var. prolifera, four new steroidal glycosides, lirioproliosides A-D, along with two known compounds, 25(S)-ruscogenin 1- O[a-L-rhamnopyranosyl(1 → 2)]β-D-xylopyranosyl(1 → 3)-β-D-fucopyranoside and ophiopogonin A, were identified. The structures of lirioproliosides A-D were established by a combination of spectroscopic and chemical methods as 25(S)-ruscogenin 1-O-[α-L-rhamnopyranosyl(1 → 2)][β-D-xylopyranosyl(1 → 3)]-β-D-fucopyranoside-3-O-α-L-rhamnopyranoside, 25(S)-ruscogenin 1-O-[3- O-acetyl-α-L-rhamnopyranosyl(1 → 2)]-β-D-fucopyranoside, 25(S)-ruscogenin (1-O-[2-O-acetyl-α-L-rhamnopyranosyl(1 → 2)]-β-D-fucopyranoside and ruscogenin (1-O-[2-O-acetyl-α-L-rhamnopyranosyl(I → 2)]-β-D- fucopyranoside, respectively. Among these steroidal glycosides, ophiopogonm A and lirioprolioside B, and lirioproliosides C and D, were isolated as epimeric pairs.
- Yu, Bo-Yang,Qiu, Sheng-Xiang,Zaw, Kyaw,Xu, Guo-Jun,Hirai, Yusuaki,Shoji, Junzo,Fong, Harry H. S.,Kinghorn, A. Douglas
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p. 201 - 206
(2007/10/03)
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