The present invention provides compounds of formula I and pharmaceutically acceptable salts thereof. The formula I compounds inhibit the tyrosine kinase activity of growth factor receptors such as VEGFR-2, FGFR-1, thereby making them useful as anti-cancer agents. The formula I compounds are also useful for the treatment of other diseases associated with signal transduction pathways operating through growth factor receptors.
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Page/Page column 14
(2008/06/13)
Hydrogen bond controlled aggregation of guanidinium-carboxylate derivatives in the solid state
In this paper, we report the synthesis and aggregation properties of new self-complementary organic molecules containing guanidinium and carboxylate groups. The crystal structures of the guanidinium carboxylates showed linear bidentate hydrogen bonding between the guanidinium and the carboxylate groups. In the case of phenyl derivative 7, steric factors force a non-planar geometry for the hydrogen bonding subunit. Substitution of the phenyl by a pyridine leads to the formation of an intramolecular hydrogen bond and a planar conformation for the subunit. As a result, the simple intramolecularly hydrogen bonded molecule maintains a rigid control of binding group disposition in a manner similar to more complex multiple fused ring systems.
Zafar, Abdullah,Melendez, Rosa,Geib, Steven J,Hamilton, Andrew D
p. 683 - 690
(2007/10/03)
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